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EC number: -
CAS number: -
The following numbers of rats died and/or proved to be pregnant:
A preliminary study has been conducted for evaluating the
potential reprotoxic effects of ammonium thioglycolate in rats and for
evaluating the correct dose to administrate to rats in the core study
(Reproductive Toxicity study with oral adminstration of ammonium
thioglycolate to rats, according to OCDE guideline n°414).
Ammonium thioglycolate was administered by gavage to
groups of 5 pregnant Wistar rats from gestation days (GD) 6 to
19 at daily doses of 1, 10, 50, 100, and 150 mg/kg. The control rats
group were treated with the vehicle, demineralized water. The rats were
killed on GD 20. The foetuses were removed, weighed, and examined for
The numbers of corpora lutea, implantations and live
foetuses per dam were not affected at the doses up to 50 mg/kg. At 50
mg/kg, the animals showed no signs of intoxication and only very
slightly reduced body weight gain during pregnancy.
At 100 mg/kg, the animals showed signs of intoxication
and 3/5 animals died. In the 2 surviving rats at 100 mg /kg, the number
of corpora lutea and implantations was unaffected, but the foetal loss
was increased. The foetuses in the 100 mg/kg dose group were lighter,
but not malformed. Then the high dose for the main
study should be lower than 100 mg/kg. At 150 mg/kg, all animals died.
conclusion, the high dose for the main study should be higher than 50
mg/kg and lower thant 100 mg/kg.
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