Registration Dossier

Diss Factsheets

Environmental fate & pathways

Biodegradation in water: screening tests

Administrative data

Endpoint:
biodegradation in water: ready biodegradability
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
Version / remarks:
17 Jul 1992
Deviations:
no
Remarks:
Minor deviations without adverse effects on study integrity.
Qualifier:
according to guideline
Guideline:
EU Method C.4-C (Determination of the "Ready" Biodegradability - Carbon Dioxide Evolution Test)
Version / remarks:
30 May 2008
Deviations:
no
Remarks:
Minor deviations without adverse effects on study integrity.
Qualifier:
according to guideline
Guideline:
other: ISO International Standard 9439 "Water Quality - Evaluation of ultimate aerobic biodegradability of organic compounds in aqueous medium - carbon dioxide evolution test."
Version / remarks:
1999
Deviations:
no
Remarks:
Minor deviations without adverse effects on study integrity.
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Trimethyl orthoacetate
EC Number:
215-892-9
EC Name:
Trimethyl orthoacetate
Cas Number:
1445-45-0
Molecular formula:
C5H12O3
IUPAC Name:
1,1,1-trimethoxyethane

Study design

Oxygen conditions:
aerobic
Inoculum or test system:
activated sludge, domestic, non-adapted
Duration of test (contact time):
28 d
Initial test substance concentrationopen allclose all
Initial conc.:
24 mg/L
Based on:
test mat.
Initial conc.:
12 mg/L
Based on:
TOC
Parameter followed for biodegradation estimation
Parameter followed for biodegradation estimation:
CO2 evolution

Results and discussion

% Degradationopen allclose all
Parameter:
% degradation (CO2 evolution)
Remarks:
based on ThCO2
Value:
45
Sampling time:
28 d
Remarks on result:
other:
Remarks:
bottle A
Parameter:
% degradation (CO2 evolution)
Remarks:
based on ThCO2
Value:
50
Sampling time:
28 d
Remarks on result:
other:
Remarks:
bottle B

Applicant's summary and conclusion

Interpretation of results:
not readily biodegradable