Registration Dossier
Registration Dossier
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EC number: 915-680-2 | CAS number: -
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo insect germ cell study: gene mutation
- Remarks:
- Drosophila Mutagenicity Assay
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 477 (Genetic Toxicology: Sex-linked Recessive Lethal Test in Drosophila melanogaster)
- GLP compliance:
- not specified
- Remarks:
- Not applicable ( prior to 1981)
- Type of assay:
- other: Drosophila mutagenesis assay
Test material
- Reference substance name:
- Reaction mass of phosphonic acid, methyl-, bis[(5-ethyl-2-methyl-2,2-dioxido-1,3,2-dioxaphosphorinan-5-yl)methyl] ester with (5-ethyl-2-methyl-2-oxido-1,3,2-dioxaphosphorinan-5-yl)methyl methyl methylphosphonate
- EC Number:
- 915-680-2
- Cas Number:
- 170836-68-7
- Molecular formula:
- not applicable for UVCB substance
- IUPAC Name:
- Reaction mass of phosphonic acid, methyl-, bis[(5-ethyl-2-methyl-2,2-dioxido-1,3,2-dioxaphosphorinan-5-yl)methyl] ester with (5-ethyl-2-methyl-2-oxido-1,3,2-dioxaphosphorinan-5-yl)methyl methyl methylphosphonate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- other: Drosophila Mutagenicity
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Details on exposure:
- Initial experimentation determined that adults could be effectively treated by confinement in a bottle with a filter papier which was saturated with the substance.
- Duration of treatment / exposure:
- 4-hour treatment results in 30-40% mortality. Larvae were treated by placing them directly on such a wick for 30 minutes.
- Control animals:
- not specified
Examinations
- Details of tissue and slide preparation:
- A 4-hour treatment results in 30-40% mortality. Larvae were treated by placing them directly on such a wick for 30 minutes.
Results and discussion
Test results
- Key result
- Sex:
- not specified
- Genotoxicity:
- not specified
- Toxicity:
- not specified
- Remarks on result:
- not determinable
Applicant's summary and conclusion
- Conclusions:
- This one dose treatment did not significantly increase the frequency of exceptions over control values in any of the assays performed in Drosophila melanogaster under the experimental conditions used.
- Executive summary:
This one dose treatment did not significantly increase the frequency of exceptions over control values in any of the assays performed in Drosophila melanogaster under the experimental conditions used.
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