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EC number: 252-091-3 | CAS number: 34562-31-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 January 2018 to 08 April 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- 2008
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- The test item is listed as PDHP (CAS # 34562-31-7), a yellow to amber colored liquid obtained from the Sponsor, Vertellus, with > 85% purity and stored at room temperature in the dark.
- Analytical monitoring:
- yes
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- The test was carried out using first instar Daphnia magna derived from in-house laboratory cultures.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 20°C to 22 °C
- pH:
- 7.8 to 8.0
- Dissolved oxygen:
- 8.4 to 9.4 mg O2/L
- Nominal and measured concentrations:
- Based on the results of the range-finding test, the definitive test was conducted with an aqueous solution of the test item at nominal concentrations of 6.25, 12.5, 25, 50 and 100% v/v saturated solution. The 100% v/v saturated solution corresponds to an initial loading rate of 50 mg/L.
- Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate was used as the reference item at concentrations of 0.32, 0.56, 1.0, 1.8 and 3.2 mg/L.
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 43 other: % v/v saturated solution
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other:
- Remarks:
- Statistically-derived value corresponding to a 43% v/v saturated solution prepared from a dilution of an initial test solution with an initial loading rate of 50 mg/L.
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- 22 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other:
- Remarks:
- Statistically-derived value corresponding to a test solution prepared as a dilution of an initial test solution with an initial loading rate of 50 mg/L, resulting in a 43% v/v saturation solution.
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 25 other: % v/v saturated solution
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other:
- Remarks:
- Statistically-derived value corresponding to a test solution prepared as a dilution of an initial test solution with an initial loading rate of 50 mg/L, resulting in a 43% v/v saturation solution.
- Duration:
- 48 h
- Dose descriptor:
- NOELR
- Effect conc.:
- 12.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other:
- Remarks:
- Test solution prepared as a dilution of an initial test solution with an initial loading rate of 50 mg/L, resulting in a 25% v/v saturation solution.
- Duration:
- 48 h
- Dose descriptor:
- LOEC
- Effect conc.:
- 50 other: % v/v saturated solution
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other:
- Remarks:
- 50% v/v saturated solution prepared from a dilution of an initial test solution with an initial loading rate of 50 mg/L.
- Duration:
- 48 h
- Dose descriptor:
- LOELR
- Effect conc.:
- 25 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other:
- Remarks:
- Test solution prepared as a dilution of an initial solution with an initial loading rate of 50 mg/L, resulting in a 100% v/v saturation solution.
- Results with reference substance (positive control):
- The results from the positive control with potassium dichromate were within the normal range for this reference item.
- Validity criteria fulfilled:
- yes
- Remarks:
- The test was considered valid since none of the control daphnids showed immobilisation or other signs of disease or stress and the oxygen concentration at the end of the test was equal to or greater than 3 mg/L in the control and test vessels.
- Conclusions:
- Acute immobilisation of Daphnia magna resulted from a 48-h exposure to a series of substance concentrations, each prepared from an initial 100% v/v saturated solution with an initial loading rate of 50 mg/L. The test concentrations included the 100% v/v saturated solution and a series of dilutions containing 6.25, 12.5, 25, and 50% v/v saturated solution. The effects concentrations were reported both as 48-h EC50 = 43% v/v saturated solution and 48-h EL50 =22 mg/L. The no effects concentrations were reported both as 48-h NOEC of 25% v/v saturated solution and 48-h NOELR of 12.5 mg/L.
Reference
Description of key information
The key study was a static acute invertebrate toxicity test on the effects of the substance on the freshwater invertebrate Daphnia magna following OECD Guideline 202. Acute immobilisation of Daphnia magna resulted from a 48-h exposure to a series of substance concentrations, each prepared from an initial 100% v/v saturated solution with an initial loading rate of 50 mg/L. The test concentrations included the 100% v/v saturated solution and a series ofdilutions containing 6.25, 12.5, 25, and 50% v/v saturated solution. The effects concentrations were reported both as 48-h EC50 = 43% v/v saturated solution and 48-h EL50 = 22 mg/L. The no effects concentrations were reported both as 48-h NOEC of 25% v/v saturated solution and 48-h NOELR of 12.5 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 22 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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