4-(3-phenylpropyl)pyridine

Eye irritation

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Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1992

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1992

Report date:

1992

Materials and methods

Test guideline

Test guideline 1

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 405 (Acute Eye Irritation / Corrosion)

Test guideline 2

Qualifier:

according to guideline

Guideline:

other: 29 CFR 1910-1200 and 16 CFR 1500.41

Principles of method if other than guideline:

The test was conducted based on US OSHA, 29 CFR, 1910.1200 and 16 CFR 1500.41

GLP compliance:

yes

Test material

Test material information

Constituent 1

Test material form:

liquid

Details on test material:

Yellowish Brown Liquid

Test animals / tissue source

Species:

rabbit

Strain:

New Zealand White

Details on test animals or tissues and environmental conditions:

Six healthy, young adult, 3 male and 3 female rabbits were used in the study.
Animals were purchased from a registered commercial breeding laboratory (Eastern Rabbit Breeding Laboratory, Taunton, MA)
Animals weighed between 2.0-3.0 kg
Animals were individually housed in seperate suspended cages.
Rooms were maintained at 68 degrees F.
12 hour dark/light periods were provided.
Animals were supplied with commercial rabbit ration and tap water ad libitum.

Test system

Vehicle:

unchanged (no vehicle)

Controls:

no

Amount / concentration applied:

A dose of 0.1 mL was administered to each animal

Duration of treatment / exposure:

Animals were checked for signs of irritation 24 hours after the substance was applied to the eye, and the eye was rinsed of any leftover test material.

Observation period (in vivo):

Observation occured 24 hours after application of substance

Duration of post- treatment incubation (in vitro):

After observation at 24 hours, the eyes were checked again at 48 and 72 hours.

Number of animals or in vitro replicates:

6 total animals were used in the study

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

24 h

Score:

6

Max. score:

110

Reversibility:

not specified

Remarks on result:

no indication of irritation

Any other information on results incl. tables

One of the six rabbits was shown to have a positive conjunctival erythema result. The test substance is considered non-irritating to the eyes.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The substance was tested in an eye irritation assay in rabbits and found to be non-irritating.