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EC number: 254-159-8 | CAS number: 38861-78-8
Table 1: Clinical signs of reaction to treatment observed in rats
No. of rats in group of 5 showing signs
Abnormal body carriage (hunched posture)
Abnormal gait (waddling)
Table 2: Individual bodyweights
Animal number and ear mark
Bodyweight (g) at
Table 3: Individual bodyweight changes
A study was performed to assess the acute oral toxicity of the test substance to the rat. The method followed was that described in:
- EEC Methods for the determination of toxicity, Directive 84/449/EEC (OJ No. L251, 19.9.84), Part B, Method B. 1. Acute toxicity (oral).
- EPA Health Effects Testing Guidelines, Subpart B - General Toxicity Testing 5798.1 175 Acute oral toxicity, September 27, 1985 (described in Federal Register Vol. 50, No. 188) and subsequent revisions. Subpart B provides detailed information relating to data requirements of 40 CFR Part 158 and supports the Toxic Substances Control Act (TSCA).
- OECD Guideline for Testing of Chemicals No. 401 "Acute Oral Toxicity". Adopted: 24 February 1987.
A group of ten fasted rats (five males and five females) was given a single dose by gavage of the test substance, as supplied, at a dose level of 2.0 g/kg bodyweight. All animals were killed and examined macroscopically on Day 15, the end of the observation period. There were no deaths. Clinical signs of reaction to treatment included pilo-erection, abnormal body carriage, abnormal gait and increased salivation; recovery was complete by Day 2. All rats achieved satisfactory bodyweight gains throughout the study. No abnormalities were recorded at the macroscopic examination on Day 15. No target organs were identified on the basis of clinical observations and macroscopic observations at necroscopy .
The acute lethal oral dose to rats was found to be greater than 2.0 g/kg bodyweight.
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