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Physical & Chemical properties

Water solubility

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Administrative data

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From January 31, 2018 to February 12, 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
not specified
Qualifier:
according to guideline
Guideline:
other: OECD Guideline 115: Surface Tension of Aqueous Solutions
Deviations:
not specified
GLP compliance:
not specified
Type of method:
flask method
Key result
Water solubility:
ca. 480 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
ca. 8
Remarks on result:
other: based on preliminary test (according to OECD 105)
Key result
Water solubility:
ca. 300 mg/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
ca. 7.6
Remarks on result:
other: based on CMC value, obtained via tensiometry measurements (according to OECD 115)

Result


The pH in solution was ca 8 and the temperature 20 degrees Celsius.


The solubility limit was 3,8567 grams in a final volume (measured volumetrically) of 8,1000 cm3.


Water solubility = Weight substance (3,8567 g)/Total volume (8,1000 cm3) = 0.4761 g/cm3


Hence, the water solubility of TMAC S was determined to be 480 g/L


The CMC value, obtained via tensiometry measurements, for the test substance was determined to be ca. 300 mg/L

Conclusions:
Under the study conditions, water solubility and the CMC based water solubility of the test substance, TMAC S, were determined to be 480 g/L and 300 mg/L, respectively.
Executive summary:

A study was conducted to determine the water solubility of the test substance, TMAC S (88.3% active), according to the OECD Guideline 105 and based on CMC, according to the OECD Guideline 115 using Du Noûy ring method. The test substance was mixed with MilliQ water at different weight ratios (20%, 30%, 40% and 60%) in order to determine the water solubility. The mixtures were shaken at 250 rpm overnight. For CMC, a stock solution of product (4 g/L) was increasingly injected (30 injections) into clean water with a surface tension of 72 mN/m. CMC is achieved when surface tension has reached a plateau. It was assumed that there are no changes in volume when mixing water and substance. Based on the shake experiments and checking for transparency, the TMAC Swater solubility limit was detected to be 480 g/L. The CMC value, obtained via tensiometry measurements, for the test substance was determined to be ca. 300 mg/L. Under the study conditions, water solubility and the CMC based water solubility of the test substance, TMAC S, were determined to be 480 g/L and 300 mg/L, respectively (Andersson, 2018).

Description of key information

The water solubility of the surface active test substance was determined using critical micelle concentration (CMC) method, according to OECD Guideline 115 (Andersson, 2018).

Key value for chemical safety assessment

Water solubility:
300 mg/L
at the temperature of:
20 °C

Additional information

The water solubility according to the OECD Guideline 105 was 480 g/L at pH 8 and 20 °C; the water solubility based on CMC was 300 mg/L. In line with the ECHA R.7a Guidance, the more reliable CMC based water solubility value for the test substance, which is a surfactant, has been taken forward for hazard/risk assessment.