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EC number: 222-477-6
CAS number: 3486-35-9
A study was conducted to evaluate the skin
irritation potential of zinc oxide in TO (outbred) strain mice.
mL of 20 % w/v zinc oxide suspension in 0.1 % Tween 80 or
vehicle was applied to clipped sites (5 cm2) of groups of six animals
for 5 consecutive days. Skin sites were observed during and after 5 d
exposure period. 24 h after the fifth daily treatment, animals were
killed and representative samples of each test and control skin sites
were analysed histologically and stained with morin dye to study
epidermal keratin binding of zinc.
No obvious reactions were observed in both
control and treatment groups after 5 d exposure. No
evidence of damage was observed upon histological examination. No morin
fluorescence was observed in skin sections.
Based on these results, 20 % w/v zinc oxide
was found to be non-irritating to mouse skin.
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