Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Particle size distribution (Granulometry)

Administrative data

Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017-05-17
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Report date:
2017

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
Qualifier:
according to guideline
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7520 (Particle Size, Fiber Length, and Diameter Distribution)
GLP compliance:
no
Type of method:
Laser scattering/diffraction
Type of particle tested:
primary particle
Type of distribution:
volumetric distribution

Test material

Constituent 1
Chemical structure
Reference substance name:
Glycine, N-acetyl-N-[3-(trifluoromethyl)phenyl]valyl-, ethyl ester
EC Number:
609-496-9
Cas Number:
379685-94-6
Molecular formula:
C18H23F3N2O4
IUPAC Name:
Glycine, N-acetyl-N-[3-(trifluoromethyl)phenyl]valyl-, ethyl ester
Test material form:
solid: particulate/powder
Remarks:
Off white to beige powder with agglomerates
Specific details on test material used for the study:
- Analytical purity: 98.5% (HPLC) - Lot/batch No.: 0161045 - Expiration date of the lot/batch: 2018/06/16

Results and discussion

Particle sizeopen allclose all
Key result
Percentile:
D10
Mean:
ca. 2 µm
St. dev.:
0
Key result
Percentile:
D50
Mean:
ca. 13.3 µm
St. dev.:
0.4
Key result
Percentile:
D90
Mean:
ca. 64.3 µm
St. dev.:
2.5

Any other information on results incl. tables

Two test series of 3 measurements each were performed with the test item:

 

Test series 1:

D10:       2.0 µm

D50:       13.0 µm         (Median diameter)

D90:       62.6 µm

 

Test series 2:

D10:       2.0 µm

D50:       13.6 µm         (Median diameter)

D90:       66.1 µm

 

Average:

D10:       2.0 µm

D50:       13.3 µm         (Median diameter)

D90:       64.3 µm

 

To conclude the test item has a median particle size D50 = 13.3 µm, which was determined by laser diffraction measurement.

 

Applicant's summary and conclusion

Conclusions:
The test item has a median particle size D50 = 13.3 µm, which was determined by laser diffraction measurement.
Executive summary:

The objective of this not GLP-compliant study was the determination of the particle size distribution of the test item according to

·             OECD Guideline 110 (1981): Particle size distribution;

·             EPA OCSPP Test Guideline830.7520 (1996): Particle size, fiber length and diameter distribution;

·             ISO 13320 (2009): Particle size analysis – Laser diffraction methods.

The test item has a median particle size D50 = 13.3 µm, which was determined by laser diffraction measurement.