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Diss Factsheets

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report date:
2017

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
March 23 2006
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
March 4 2016
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Version / remarks:
August 1996
GLP compliance:
yes
Type of method:
effusion method: isothermal thermogravimetry

Test material

Constituent 1
Chemical structure
Reference substance name:
(R)-quinuclidin-3-ol
EC Number:
246-857-6
EC Name:
(R)-quinuclidin-3-ol
Cas Number:
25333-42-0
Molecular formula:
C7H13NO
IUPAC Name:
quinuclidin-3-ol
Test material form:
solid: crystalline

Results and discussion

Vapour pressureopen allclose all
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
0.006 Pa
Test no.:
#1
Temp.:
25 °C
Vapour pressure:
0.016 Pa

Any other information on results incl. tables

Table 1          
Results of the Vapour pressure Isothermal TGA Analysis

Temperature
[°C]

Weight loss
[µg/min]

νT
[g/cm2/h]

logνT

logPT

PT
[Pa]

60

2.12312

2.53´10-4

-3.60

0.53

3.4

 

2.13331

2.55´10-4

-3.59

0.54

3.4

70

6.12167

7.31´10-4

-3.14

1.12

13

 

6.31830

7.54´10-4

-3.12

1.14

14

80

16.0905

1.92´10-3

-2.72

1.66

46

 

17.0170

2.03´10-3

-2.69

1.69

49

90

40.1075

4.79´10-3

-2.32

2.17

1.5´102

 

43.0043

5.13´10-3

-2.29

2.21

1.6´102

 

Table 2          
Vapour Pressure of the Test Item

Temperature
[°C]

logPT

PT
[Pa]

PT
[mm Hg]

20

-2.18

6.5´10-3

4.9´10-5

25

-1.80

1.6´10-2

1.2´10-4

Applicant's summary and conclusion

Conclusions:
The vapour pressure of the test item at 20°C (293K) and 25°C (298K) was 0.0065 and 0.016 Pa, respectively.