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EC number: 281-928-5 | CAS number: 84066-92-2
The gravimetric and nominal chamber concentrations were 1.04 and 10.95 mg/L respectively. The mass median aerodynamic diameter was calculated to be 1.94 μm based on graphic analysis of the particle size distribution as measured with an ACFM Andersen Ambient Particle Sizing Sampler.
All animals survived exposure to the test atmosphere. Following exposure, all rats exhibited abnormal respiration. In addition, two males and one female showed signs of abdominal distention and/or ano-genital staining and reduced fecal volume. Ocular and nasal discharge and facial staining were also noted for this female. All five males and four female recovered from the above symptoms by Day 6. Although all rats lost body weight by Day 1 and/or through Day 3, all animals showed a weight gain over the course of the 14 day study. Apart from irregular respiration persisting through Day 14, the fifth female recovered from all other symptoms by Day 12 and showed improved health through weight gain by study termination (Day 14). No gross abnormalities were noted for any of the animals when necropsied at the conclusion of the 14-day observation period.
The gravimetric and nominal chamber concentrations were 5.12 and 99.61 mg/L respectively. The mass median aerodynamic diameter was calculated to be 2.36 μm based on graphic analysis of the particle size distribution as measured with an ACFM Andersen Ambient Particle Sizing Sampler.
Following exposure to the test atmosphere, all rats exhibited clinical signs including abnormal respiration, hypoactivity, nasal and ocular discharge, ano-genital staining, tremors and/or an unthrifty appearance. One female was found dead on Day 1, three males and a second female died on Day 2 and a third female died by Day 3. The fifth male showed signs of opacity in one eye, a
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