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Physical & Chemical properties

Solubility in organic solvents / fat solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From November 08, 2017 to February 20, 2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
other: CIPAC method MT 181
Deviations:
no
GLP compliance:
no
Remarks:
The study was conducted in a facility which operates in accordance with Good Laboratory Practice principles; however no claim of GLP compliance was intended nor is made for this study
Key result
Medium:
n-octanol
Solubility:
ca. 133 - ca. 160 g/L
Temp.:
20 °C
Test substance stable:
not determined

Results

Preliminary test

The recorded observations for the contents of the cylinder after each addition of n-octanol are shown in the following table:

Total Volume of

n-Octanol Added (mL)

Saturation Concentration (g/L)

Observations

0.5

232

Clear pale yellow solution, excess test test substance present

1

116

Clear pale yellow solution, no excess test test substance present

The solubility was estimated to bein the range 100 to 200 g/L and definitive testing was continued using the MT 181 method.

Definitive Test

The recorded observations for the contents of the cylinder after each addition of n-octanol are shown in the following tables:

  Sample 1

Total Volume of

n-Octanol Added (mL)

Saturation Concentration (g/L)

Observations

2

203

Transparent, pale yellow solution, excess test test substance present

2.5

162

Transparent, pale yellow solution, excess test test substance present

3

135

Transparent, pale yellow solution, no excess test test substance present

 Sample 2

Total Volume of

n-Octanol Added (mL)

Saturation Concentration (g/L)

Observations

2

206

Transparent, pale yellow solution, excess test test substance present

2.5

165

Transparent, pale yellow solution, excess test test substance present

3

137

Transparent, pale yellow solution, no excess test test substance present

The solubility was estimated to be in the range 133 to 160 g/L.

Conclusions:
Under the study conditions, the n-octanol solubility of the test substance was determined to be in the range 133 to 160 g/L at 20.0 ± 0.5°C.
Executive summary:

A study was conducted to determine the n-octanol solubility of the test substance by visual observation based on CIPAC method MT 181. Under the study conditions, the n-octanol solubility of the test substance was determined to be in the range of 133 to 160 g/L at 20.0 ± 0.5°C (Envigo, 2018)

Description of key information

The n-octanol solubility of the test substance was determined by visual observation based on CIPAC method MT 181 (Envigo, 2018).

Key value for chemical safety assessment

At the temperature of:
20 °C
Solubility in organic solvents at 20°C:
160 g/L

Additional information

Value used for CSA: 160 g/L at 20 ± 0.5°C

The n-octanol solubility of the test substance was determined to be in the range 133 to 160 g/L at 20 ± 0.5°C.

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