Reaction mass of L-Glutamic acid, N-coco acyl derivs., monosodium salts and sodium hydrogen N-(1-oxooctadecyl)-L-glutamate

Endpoint summary

Description of key information

Based on the modelled conditions, the subacute NOAEL of the test material in the rat was determined to be ca. 73 mg/kg bw/day.

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Link to relevant study records

Reference

Reference 1

Endpoint:

repeated dose toxicity: oral, other

Remarks:

Both subchronic and subacute data were used in the prediction. As a worst case, the prediction is submitted as subacute toxicity data.

Type of information:

(Q)SAR

Adequacy of study:

key study

Study period:

2018

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The following prediction was performed using the OECD QSAR Toolbox using an appropriate category based on the current endpoint. The prediction was further refined using subcategories.

Justification for type of information:

A read-across justification report (RAAF) will be added to Section 13 as soon as possible.

Qualifier:

according to guideline

Guideline:

other:

Version / remarks:

REACH Guidance on QSARs R.6, May/July 2008

Principles of method if other than guideline:

The repeat dose oral toxicity of the test material was evaluated using a read-across approach. Suitable analogues were found in the OECD QSAR Toolbox using the Organic Functional Groups category, and the results were refined using relevant subcategories.

GLP compliance:

no

Remarks:

As no laboratory work took place, compliance with GLP is not required.

Limit test:

no

Specific details on test material used for the study:

SMILES: CCCCCCCCCCCCCCCC(=O)NC(CCC(O)=O)C(O)=O

Species:

rat

Strain:

not specified

Sex:

not specified

Route of administration:

oral: unspecified

Key result

Dose descriptor:

NOAEL

Effect level:

73 mg/kg bw/day (nominal)

Based on:

test mat.

Sex:

not specified

Basis for effect level:

other: Based on the modelled conditions

Remarks on result:

other: The prediction was based on the average value from the 4 nearest neighbours compared by prediction descriptors.

Critical effects observed:

not specified

The prediction was based on dataset comprised from the following descriptors: NOEL

Estimation method: Takes average value from the 4 nearest neighbours

Domain logical expression: Result: In Domain

Substances used for the prediction should be:

Carboxylic acid<OR>Organic amide and thioamide<OR>Surfactants - Anionic (Organic functional groups)

Not categorized (Repeat dose (HESS))

Not bioavailable (Lipinski Rule Oasis)

Conclusions:

Based on the modelled conditions, the subacute NOAEL of the test material in the rat was determined to be ca. 73 mg/kg bw/day

Executive summary:

The repeat dose oral toxicity of the test material was evaluated using a read-across approach. Suitable analogues were found in the OECD QSAR Toolbox using the Organic Functional Groups profiler, and the results were refined using relevant subcategories (repeat dose (HESS) and lipinski rules oasis).

The target chemical falls within the applicability domain of the prediction.

Based on the modelled conditions, the subacute NOAEL of the test material in the rat was determined to be ca. 73 mg/kg bw/day.

Reference 2

Endpoint:

repeated dose toxicity: oral, other

Remarks:

Both subchronic and subacute data were used in the prediction. As a worst case, the prediction is submitted as subacute toxicity data.

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: read across conducted on QSAR assessment

Justification for type of information:

The test material is a mixture of many components. Comparison of all substances has shown that they are expected to have the same repeat dose toxicity. For the purpose of addressing the repeat dose endpoint the most concentrated component of the test material was assessed individually.

Reason / purpose for cross-reference:

read-across source

Dose descriptor:

NOAEL

Effect level:

73 mg/kg bw/day (nominal)

Based on:

test mat.

Sex:

not specified

Basis for effect level:

other: Based on the modelled conditions. Read across from the most concentrated component.

Remarks on result:

other: The prediction was based on the average value from the 4 nearest neighbours compared by prediction descriptors.

Remarks:

Read across from the most concentrated component.

Critical effects observed:

not specified

Conclusions:

Based on the modelled conditions, the subacute NOAEL of the test material in the rat was determined to be ca. 73 mg/kg bw/day.

Executive summary:

The potential of the component present at the highest concentration in the test material to cause repeat dose toxicity was modelled using the OECD Toolbox. The NOAEL was predicted to be 73 mg/kg bw/day. It has been shown, using read across, that all components are expected to have the same toxicity. Therefore, the NOAEL of the target chemical in rat is predicted to be 73 mg/kg bw/day.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Repeated dose toxicity: inhalation - systemic effects

Endpoint conclusion

Endpoint conclusion:

no study available

Repeated dose toxicity: inhalation - local effects

Endpoint conclusion

Endpoint conclusion:

no study available

Repeated dose toxicity: dermal - systemic effects

Endpoint conclusion

Endpoint conclusion:

no study available

Repeated dose toxicity: dermal - local effects

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

The repeat dose oral toxicity of the test material was evaluated using a read-across approach. Suitable analogues were found in the OECD QSAR Toolbox using the Organic Functional Groups profiler, and the results were refined using relevant subcategories (repeat dose (HESS) and lipinski rules oasis).

The target chemical falls within the applicability domain of the prediction.

Based on the modelled conditions, the subacute NOAEL of the test material in the rat was determined to be ca. 73 mg/kg bw/day.

Justification for classification or non-classification

In accordance with the criteria for classification as defined in Annex I, Regulation (EC) No. 1272/2008 (CLP), the substance does not require classification with respect to Specific Target Organ Toxicity repeated dose (STOT RE) via the oral route.