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Administrative data

Endpoint:
relative self-ignition temperature (solids)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
27 September - 06 November 2001
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2002
Report date:
2002

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.16 (Relative Self-Ignition Temperature for Solids)
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
439-750-2
EC Name:
-
Cas Number:
183487-56-1
Molecular formula:
Hill formula: C17H19BrClNO3 CAS formula: C17H19BrClNO3
IUPAC Name:
(14S)-4-bromo-2-methoxy-7-methyl-17-oxa-7-azatetracyclo[12.2.1.0^{5,16}.0^{10,15}]heptadeca-1,3,5(16),10-tetraen-12-one hydrochloride
Test material form:
solid: particulate/powder
Details on test material:
- Name of test material (as cited in study report): JNJ-16169374-AAC (T002113)
- Physical state: solid (powder)
- Appearance: off-white powder
Specific details on test material used for the study:
- Batch n°: RT002113G3A231
- Analytical purity: 92.9%
- Expiration date: 01 December 2001
- Storage condition: at room temperature

Results and discussion

Relative self-ignition temperature (solids)
Key result
Relative self-ignition temperature:
337 °C
Remarks on result:
other: Ambient pressure is anticipated
Remarks:
at atm. press. of 101.3 kPa

Any other information on results incl. tables

Applying a linear increase in temperature of about 0.5°C/min, T002113 showed an exothermic reaction starting at about 200°C. A Maximum temperature of about 529°C was measured in the sample cube during the exothermic reaction. At the end of the measurement, a rusty ash remained. T002113 shows a relative self-ignition temperature at about 337°C.

Applicant's summary and conclusion

Conclusions:
T002113 is auto-flammable under the conditions of the test.

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