Registration Dossier

Administrative data

Description of key information

Acute oral toxicity studies were conducted on two TDI-I category members, Diurea 8 and Tetraurea 2. The results from these studies showed no evidence of acute toxicity up to the highest dose tested in either study (2000 mg/kg test item in arachis oil BP). There is no evidence of a relevent intrinsic acute oral toxicity requiring classification or substance specific risk management measures.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating dose
Value:
2 000 mg/kg bw
Quality of whole database:
High

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

The oral LD50 value is greater than 2000 mg/kg bw in both studies conducted on the TDI-I category, therefore, existing data supports justification for non-classification.