Registration Dossier
Registration Dossier
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EC number: 246-279-4 | CAS number: 24468-28-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study not performed to GLP and no guideline stated but meets the basic requirements of a guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Details on test material:
- - Name of test material (as cited in study report): Crude cyanuric acid
- Physical state: off-white solid balls
- Lot/batch No.: Lot 3-30-81
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Isaac’s Farm, Litchfield, Illinois, USA
- Age at study initiation: Young adults
- Weight at study initiation: 2.51 – 2.79 kg
- Diet (e.g. ad libitum): provided ad libitum
- Water (e.g. ad libitum): provided ad libitum
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- physiological saline
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Dorsal surface
- % coverage: 10%
- Type of wrap if used: Latex rubber
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Test material wiped from animal
- Time after start of exposure: ~ 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 5000 mg/kg - Duration of exposure:
- ~ 24 hours
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 10
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observations made 3 times during the first 8 hours of the study and twice daily thereafter. Body weights recorded on day 0, 7 and 14.
- Necropsy of survivors performed: yes (day 15) - Statistics:
- None applied
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No mortalities occurred.
- Clinical signs:
- No clinical abnormalities were observed.
- Body weight:
- No effects on body weights were noted.
- Gross pathology:
- Pale kidneys in one male, pale, mottled kidneys in one female, tapeworm cysts in one female. None of the effects were attributed to toxicity of the test material.
Any other information on results incl. tables
Males: No clinical abnormalities were observed. No necropsy findings were attributed to toxicity of the test material. One animal had pale kidneys.
Females: No clinical abnormalities were observed. No necropsy findings were attributed to toxicity of the test material. One animal had pale mottled kidneys and another had tapeworm cysts in the mesentery.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information
- Conclusions:
- LD50 (dermal, rabbit) > 5000 mg/kg
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