Registration Dossier
Registration Dossier
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EC number: 240-894-1 | CAS number: 16871-71-9
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- repeated dose toxicity: other route
- Type of information:
- other: evidence from degradation product
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- European Union Risk Assessment Report - Zinc metal
- Author:
- Ministry of Housing, Spatial Planning
and the Environment (VROM) - Year:
- 2 008
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Zinc
- EC Number:
- 231-175-3
- EC Name:
- Zinc
- Cas Number:
- 7440-66-6
- Molecular formula:
- Zn
- IUPAC Name:
- zinc
- Details on test material:
- no information on test material used
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Executive summary:
Based on the ICDZ data (Cleven et al., 1993) on bioaccumulation of zinc in animals and on
biomagnification (i.e. accumulation and transfer through the food chain), it is concluded that
secondary poisoning is considered to be not relevant in the effect assessment of zinc. Major
decision points for this conclusion are the following. The accumulation of zinc, an essential
element, is regulated in animals of several taxonomic groups, for example in molluscs,
crustaceans, fish and mammals. In mammals, one of the two target species for secondary
poisoning, both the absorption of zinc from the diet and the excretion of zinc, are regulated.
This allows mammals, within certain limits, to maintain their total body zinc level (whole
body homeostasis) and to maintain physiologically required levels of zinc in their various
tissues, both at low and high dietary zinc intakes. The results of field studies, in which
relatively small differences were found in the zinc levels of small mammals from control and
polluted sites, are in accordance with the homeostatic mechanism. These data indicate that the
bioaccumulation potential of zinc in both herbivorous and carnivorous mammals will be low.
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