Dilithium tetraborate

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

14th September 2017 - 17th October 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

ISO 13320 (Particle size analysis - Laser diffraction methods)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

Laser scattering/diffraction

Mass median aerodynamic diameter:

149.794 µm

Key result

Percentile:

D10

Mean:

65.624 µm

St. dev.:

0.291

Key result

Percentile:

D50

Mean:

149.794 µm

St. dev.:

0.423

Key result

Percentile:

D90

Mean:

265.262 µm

St. dev.:

0.381

During the method development phase of the analysis trials were conducted using the dry powder module (DPM). The results of these trials indicated that the most appropriate test and material parameters to obtain the optimum measurements were:

Module : DPM

Dispersant : Air

Dispersion pressure : 0.0 barg

Refractive index (sample) : 1.500 n

Absorption : 0 AU

Analysis Model : General Purpose (Normal)

Using the identified parameters, the particle size was analysed over the range 0.02 μm to 2000 μm. The full results are presented below in Table 1.

Table 1: Full Test Results

	RUN 1	RUN 2	RUN 3	RUN 4	RUN 5	Average*
Volume weighted mean	157.814	158.141	157.691	158.120	158.674	158.088
Median	149.338	149.875	149.398	149.843	150.515	149.794
Mode	167.940	168.439	167.805	168.541	168.937	168.334
d10 - 10 % of material is <	65.303	65.692	65.556	65.442	66.150	65.624
d50 - 50 % of material is <	149.338	149.875	149.398	149.843	150.515	149.794
d90 - 90 % of material is <	265.363	265.250	264.557	265.435	265.696	265.262

All results are in μm

* Average result is calculated from the entirety of data captured in each run and is not a simple

arithmetic mean

 

The coefficient of variation was determined to be <3% for d50 and <5% for d10 and d90. The repeatability of the results were therefore considered acceptable and within the acceptable limits as per the ISO 13320-1 test standard.

Conclusions:

The particle size distribution for dilithium tetraborate was determined. The values obtained for d10, d50 and d90 were 65.624, 149.794 and 265.262 μm respectively (a mean of 5 runs).

Executive summary:

The test was conducted according to ISO 13320:2009 and CIPAC MT 187 to determine the particle size distribution of dilithium tetraborate.

The values obtained for d10, d50 and d90 were 65.624, 149.794 and 265.262 μm respectively (a mean of 5 runs).

The coefficient of variation determined for d50 was less than 3% and for d10 and d90 were less than 5%. The repeatability of the particles size distribution were therefore within the acceptable limits as per the ISO 13320-1 test standard.

Description of key information

The particle size distribution for dilithium tetraborate was determined.  The values obtained for d10, d50 and d90 were 65.624, 149.794 and 265.262 μm respectively (a mean of 5 runs).