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EC number: 251-833-3 | CAS number: 34122-40-2
The acute oral toxicity of the test item was assessed via an up-and-down procedure which followed the OECD 425 TG (2001). In brief, fasted female rats were individually dosed with the test item (suspended in corn oil) via intragastric intubation. The doses selected were 2000, 550, and 175 mg/kg. The maximum starting dose was chosen based on available toxicity data. Dosed rats were observed for mortality, body weight changes, and clinical signs for up to 14 days post-treatment. Surviving rats were necropsied to assess gross pathological effects. All rats treated with the starting dose (2000 mg/kg) were found dead by the day after dosing. Clinical signs in this dose group included tremors, staining, clear oral discharge, hair loss, wet chin, arching back during handling or ataxia. In the 500 mg/kg dose group, clinical signs such as diarrhea, hair loss, staining, red nasal discharge, or wet fur were observed. No clinical signs were observed in the rat dosed at 175 mg/kg. No gross lesions were present in the rats at necropsy. Based on the results of the study, the oral LD50was estimated to be 939.8 mg/kg in female rats.
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