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Physical & Chemical properties

Vapour pressure

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Description of key information

Valid experimental study (pretest type data) with use of a vapour pressure balance (Knudsen effusion method as described in EU testing guideline A.4). Analytical Development Physical Chemistry, Schering AG Berlin. Study report No. A05406 (ADP 2001_163), dated 2001-09-01.

Result: The vapour pressure of testosterone at 25°C is < 0.001 Pa.

Key value for chemical safety assessment

Additional information

The vapour pressure of testosterone was determined using a screening method based on the detection of the evaporation rate from a Knudsen cell of a vapour pressure balance at 25°C.

Testosterone was mixed with three other compounds. From all four test substances low or very low vapour pressures, based on the study directors experience were expected. For this reason the experiments consisted in the measurement of the evaporation rate of the mixture from a Knudsen cell at 25°C. Since the evaporation rate of the mixture was below the value derived from the lower limit of the vapour pressure range recommended for use of a vapour pressure balance (10-3Pa, EU testing guideline A.4) it can be assumed that the vapour pressure of the mixture is lower than 10-3Pa.

Considering this this fact, the vapour pressure of the single compounds in the mixture has also to be lower than 10-3Pa.

Therefore, the vapour pressure of testosterone can be estimated to be at 25°C :

p25< 10-3Pa