Fatty acids, C18 unsatd., mono- and diesters with triethanolamine, di-Me sulfate quaternized

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

REPORTING FORMAT FOR THE ANALOGUE APPROACH
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
The hypothesis for this analogue approach is that target and source substances, being different compounds, have similar (eco) toxicological properties based on structural similarity with common functional groups; a quaternized ethanolamine moiety, one to three ester groups with a typical UVCB distribution with long-chain fatty acids of natural origin.
Furthermore identical precursors (triethanolamine, long-chain fatty acids, dimethyl sulphate) are used for manufacturing. Therefore common breakdown products via physical and biological processes, which result in structurally similar chemicals, are evident.
For further information refer to general justification for read-across attached to chapter 13 of this IUCLID file.

2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
See general justification for read-across attached to chapter 13 of this IUCLID file.

3. ANALOGUE APPROACH JUSTIFICATION
See general justification for read-across attached to chapter 13 of this IUCLID file.

4. DATA MATRIX
See general justification for read-across attached to chapter 13 of this IUCLID file.

Reason / purpose for cross-reference:

read-across: supporting information

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across: supporting information

Key result

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

2.23 mg/L

Nominal / measured:

estimated

Conc. based on:

act. ingr.

Basis for effect:

mobility

Remarks on result:

other: key study

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

6.05 mg/L

Nominal / measured:

meas. (geom. mean)

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: supporting study

Description of key information

The following effect value was derived forFatty acids, C18 unsatd., mono and diester with triethanolamine , di-Me sulfate-quaternized based on read-across information from thepartially unsaturated TEA-Esterquat:

48 h EC50 = 2.23 mg a.i./L

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

2.23 mg/L

Additional information

No experimental data on the short-term toxicity to aquatic invertebrates are available for the target substance Fatty acids, C18 unsatd., mono and diester with triethanolamine , di-Me sulfate-quaternized. However, reliable relevant data are available for the closely related source substance partially unsaturated TEA-Esterquat.

 

The 48 hr acute toxicity of partially unsaturated TEA-Esterquat (solvent free) to water flea (Daphnia magna) according to EU Method C.2 (Acute Toxicity for Daphnia) was studied under static conditions.  Daphnids were exposed to control, and partially unsaturated TEA-Esterquat (solvent free) at nominal concentration of 1, 2.2, 4.84, 10.6, 23.4, 51.5, 113 mg test mat./L for 48 hr.  Mortality/immobilization was observed daily. The 48 hour EC50 was 2.23 mg a.i./L. The effect concentration was corrected for the analytical recovery of 93%.

In a supporting study, the 48 hr acute toxicity of partially unsaturated TEA-Esterquat (CAS No. 157905-74-3) was investigated in a study conducted according to OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test). Under static conditions Daphnia magna were exposed to control and test chemical at nominal concentration of 0.2, 0.44, 0.97, 2.13, 4.69, 10.3, 22.7 mg/L (mean measured concentration: 0.09, 0.2, 0.43, 0.95, 2.1, 4.6, 10.1 mg/L). The mean concentrations during the test (mean of samples taken at 0 h and 48 h) were between 34.7 % and 51.7 % of nominal (average 44.5 %). Immobilization and sublethal effects were observed daily. The 48 hour EC50 based on mean measured concentrations was 6.05 mg/L.

The lowest 48 h EC50 in Daphnia of 2.23 mg a.i./L was used for chemical safety assessment.

Justification for read-across

The read-across is built on the hypothesis that target and source substances, being different compounds, have similar(eco) toxicologicalproperties based on structural similaritywith common functional groups. A detailed justification for read-across is attached to chapter 13 of the IUCLID file.