Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Biodegradation in water:

The biodegradability of the substance was calculated using seven different Biowin 1-7 models of the BIOWIN v4.10 software. The results indicate that test chemical is expected to be not readily biodegradable.

Bioaccumulation: aquatic / sediment:

From BCFBAF (v3.00) model of EPI suite, the estimated bio concentration factor (BCF) for chemical is 3.162 L/kg wet-wt.

Additional information

Biodegradation in water:

Following different studies includes estimated study for the target chemical and experimental study for read-across analogues which is extracted by using mechanistic approach and functionally and structurally similar to the target chemical to observe the biodegradation rate of test chemical in water.

Estimation Programs Interface Suite was run to predict the biodegradation potential of the test compound in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI LInear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1 -7, respectively) of the BIOWIN v4.10 software. The results indicate that test chemical is expected to be not readily biodegradable.

In second study, aerobic biodegradation experiment was performed for read across chemical using activated sludge at concentration 0.5 g/L dry material as inoculums and initial concentration of chemical taken was 100 mg/L for 42 days. By considering DOC removal parameter read across chemical showed 16 % degradation in 42 days. The read across chemical belongs to D category according to table 1 and 2 as its limit value falls in that range. This percentage value is very less So it is concluded that test chemical is not readily biodegradable.

Last biodegradation study was conducted for 14 days for evaluating the percentage biodegradability of read across chemical. Activated sludge was used as a test inoculums for the study. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. After 14 days of incubation Percent biodegradation of read across chemical was observed to be 0% by BOD parameter and 0.7% by HPLC parameter. Thus, based on percentage degradation, read across chemical is considered to be not readily biodegradable in water.

Based on above observations, it is concluded that test chemical is not readily degradable in water.

Bioaccumulation: aquatic / sediment:

Following different studies includes estimated study for the target chemical and experimental study for read-across analogues which is extracted by using mechanistic approach and functionally and structurally similar to the target chemical to observe the bioaccumulation of test chemical.

First predicted report from BCFBAF (v3.00) model of EPI suite, which indicate the estimated bio concentration factor (BCF) for test chemical is 3.162 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000.Thus it is concluded that test chemial is not expected to bio accumulate in fish and in the food chain.

 

And another supporting evidence from PBT profiler suggest the Bioaccumulation factor (BCF) for test substance was estimated to be 3.2 L/kg wet-wt at 25 deg.C. Based on the BCF concentration it is concluded that the test chemical is non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.

The next study was conducted to determine the bioaccumulation of test chemical in Cyprinus carpio. The test was conducted at two different nominal concentrations of 20 ug/l and 2 ug/l for 6 wk of exposure period. The lipid concentration in organism was observed to be 4.4 %. Range finding study involve the LC50(48h) 1.35 mg/L, Rice fish (Oryzias latipes). HCO-40 used as a vehicle at 1st Concentration area: 600 ug/L and 2nd Concentration area: 60 ug/L. The Bioaccumulation factor (BCF) for the substance was determined to be ranges from 198-350 L/kg for 20 ug/l and 177-370 L/kg for 2 ug/l. After the exposure of test chemical withCyprinus carpio for 6 wk, it was observed that the chemical non bioaccumulative in nature as it does not exceed the BCF criteria of 2000.

The last is from authoritative database HSDB, the BCF value of test chemical was estimated to be 25 dimensionless by using an estimated log Kow of 2.14 and a regression derived equation. On the basis of this estimated BCF value it can be concluded that test chemical in non bioaccumulative in nature.

 

Thus above both prediction results and experimental studies of read across chemical conclude the test chemical is non bio accumulate in the aquatic environment.