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EC number: 262-987-6 | CAS number: 61788-56-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 04 September 2017 - 04 November 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 27 July 1995
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 30 May 2008
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- - Source and lot/batch No.of test material: A065/99
- Expiration date of the lot/batch: 1st July 2019
- Purity: UVCB - Key result
- Remarks on result:
- not determinable
- Details on results:
- Sample number 1 (10 g/L loading rate) remained visibly saturated with a dispersion of excess, undissolved test item even after centrifugation and filtration. Although sample number 2 (1.0 g/L loading rate) and sample number 3 (0.1 g/L loading rate) solutions were visibly clear and colorless after centrifugation, the supernatants still presented a strong Tyndall beam, indicating light scattering originating from a dispersion of emulsified, excess, undissolved material remaining suspended in the solution. On filtration of the supernatants through a 0.2 μm filter, the Tyndall beam response remained in the resulting filtrate, indicating a colloidal nature to the dispersion.
The behaviour of the test item in an aqueous environment was as expected, based on its chemical structure and composition. The significant surface-active properties presented by the test item resulted in the formation of a colloidal (< 0.2 μm) dispersion of excess, undissolved test item throughout the saturated solution. As this dispersed, excess, undissolved material could not be satisfactorily removed by either centrifugation of filtration techniques, it was not possible to isolate a genuine saturated aqueous solution of test item suitable for analysis and quantification.
An additional preliminary evaluation sample was also prepared on instruction by the Study Director, but has not been presented in this report. This was since this sample was not evaluated over a sufficient time period to be relevant to the regulatory methods for the determination of water solubility. - Conclusions:
- No determination of water solubility was feasible for the test item.
- Executive summary:
Envigo (2018) is a GLP-compliant study following OECD guideline 105 and is considered reliable without restrictions (Klimisch 1). A flask method was used to determine water solubility. No determination of water solubility was feasible for the test item. This was due to the test item, representative of the chemical class of anionic surfactants, showing significant surface-active properties in an aqueous environment. When attempting to generate saturated solutions, a colloidal suspension (i.e. containing micelles < 0.2 µm) was formed. As this dispersed, excess, undissolved material could not be satisfactorily removed by either centrifugation of filtration techniques, it was not possible to isolate a genuine saturated aqueous solution of test item suitable for analysis and quantification.
Reference
Description of key information
No determination of water solubility was feasible for the test item.
Key value for chemical safety assessment
Additional information
Envigo (2018) is a GLP-compliant study following OECD guideline 105 and is considered reliable without restrictions (Klimisch 1). A flask method was used to determine water solubility. No determination of water solubility was feasible for the test item. This was due to the test item, representative of the chemical class of anionic surfactants, showing significant surface-active properties in an aqueous environment. When attempting to generate saturated solutions, a colloidal suspension (i.e. containing micelles < 0.2 µm) was formed. As this dispersed, excess, undissolved material could not be satisfactorily removed by either centrifugation of filtration techniques, it was not possible to isolate a genuine saturated aqueous solution of test item suitable for analysis and quantification.
As lithium naphthenate is a UVCB consisting of a large number of different constituents, water solubility values have been predicted for representative structures within the UVCB. The QSAR model WATERNT v 1.01 was used and the study was assigned a reliability score of 2 (Reliable with restrictions) as it is an accepted calculated method. The water solubility predictions of the representative constituents of lithium naphthenate are in the range of 3.1 E-07 to 1887.6 mg/L
As lithium naphthenate is a UVCB consisting of a large number of different constituents, water solubility values have been predicted for representative structures within the UVCB. The QSAR model WSKOWWIN v 1.42 was used and the study was assigned a reliability score of 2 (Reliable with restrictions) as it is an accepted calculated method. The water solubility predictions of the representative constituents of lithium naphthenate are in the range of 9.367 E-07 to 5.141 E+05 mg/L.
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