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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2004
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Deviations:
not specified
GLP compliance:
yes
Radiolabelling:
no
Analytical monitoring:
yes
Duration:
5 d
pH:
4
Duration:
5 d
pH:
7
Duration:
5 d
pH:
9
Positive controls:
no
Negative controls:
no
Transformation products:
not measured
% Recovery:
> 90
pH:
4
Duration:
5 d
Remarks on result:
hydrolytically stable based on preliminary test
% Recovery:
> 90
pH:
7
Duration:
5 d
Remarks on result:
hydrolytically stable based on preliminary test
% Recovery:
> 90
pH:
9
Duration:
5 d
Remarks on result:
hydrolytically stable based on preliminary test
Key result
pH:
4
DT50:
> 5 d
Type:
not specified
Remarks on result:
hydrolytically stable based on preliminary test
Key result
pH:
7
DT50:
> 5 d
Type:
not specified
Remarks on result:
hydrolytically stable based on preliminary test
Key result
pH:
9
DT50:
> 5 d
Type:
not specified
Remarks on result:
hydrolytically stable based on preliminary test

10mg/l of the test solutions were prepared with pH values of 4, 7 and 9 buffer solutions (n=2). Concentrations in test solutions were measured by HPLC.
Result: More than 90 % of initial concentrations in all test solutions were detected after 5 days of shaking.

Residue of the test substance after 5 days
pH 4: 102%, 99.9% (average: 101%)
pH 7: 103%, 102% (average: 102%)
pH 9: 101%, 99.0% (average: 99.8%)

Description of key information

The test substance is stable in water.

Key value for chemical safety assessment

Additional information

10mg/l of the test solutions were prepared with pH values of 4, 7 and 9 buffer solutions (n=2). Concentrations in test solutions were measured by HPLC.
Result: More than 90 % of initial concentrations in all test solutions were detected after 5 days of shaking.

Residue of the test substance after 5 days
pH 4: 102%, 99.9% (average: 101%)
pH 7: 103%, 102% (average: 102%)
pH 9: 101%, 99.0% (average: 99.8%)