Registration Dossier
Registration Dossier
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EC number: 202-803-3 | CAS number: 99-94-5
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- not specified
- GLP compliance:
- yes
- Radiolabelling:
- no
- Analytical monitoring:
- yes
- Duration:
- 5 d
- pH:
- 4
- Duration:
- 5 d
- pH:
- 7
- Duration:
- 5 d
- pH:
- 9
- Positive controls:
- no
- Negative controls:
- no
- Transformation products:
- not measured
- % Recovery:
- > 90
- pH:
- 4
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- % Recovery:
- > 90
- pH:
- 7
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- % Recovery:
- > 90
- pH:
- 9
- Duration:
- 5 d
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 4
- DT50:
- > 5 d
- Type:
- not specified
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 7
- DT50:
- > 5 d
- Type:
- not specified
- Remarks on result:
- hydrolytically stable based on preliminary test
- Key result
- pH:
- 9
- DT50:
- > 5 d
- Type:
- not specified
- Remarks on result:
- hydrolytically stable based on preliminary test
Reference
10mg/l
of the test solutions were prepared with pH values of 4, 7 and 9 buffer
solutions (n=2). Concentrations in test solutions were measured by HPLC.
Result: More than 90 % of initial concentrations in all test solutions
were detected after 5 days of shaking.
Residue of the test substance after 5 days
pH 4: 102%, 99.9% (average: 101%)
pH 7: 103%, 102% (average: 102%)
pH 9: 101%, 99.0% (average: 99.8%)
Description of key information
The test substance is stable in water.
Key value for chemical safety assessment
Additional information
10mg/l
of the test solutions were prepared with pH values of 4, 7 and 9 buffer
solutions (n=2). Concentrations in test solutions were measured by HPLC.
Result: More than 90 % of initial concentrations in all test solutions
were detected after 5 days of shaking.
Residue of the test substance after 5 days
pH 4: 102%, 99.9% (average: 101%)
pH 7: 103%, 102% (average: 102%)
pH 9: 101%, 99.0% (average: 99.8%)
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