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EC number: 278-108-4 | CAS number: 75199-00-7
Results of the pre-test
- Intradermal induction
After 24 hours the skin around the injection side were dyed golden-yellow
- Topical induction
Table 2: Results for skin reaction after topical application in the pre-test
No animals died during the experimantal phase and the body weight gain was comparable to the control animals.
Results of the main test
Table 3: Individual results of the 1. Challenge
Test material concentration
1. Control group
* = Application site partly scaly
Table 4: Individual results of the 2. Challenge
+ = Application site partly encrusted
In a dermal sensitization study conducted according to OECD 406, young female BOR : DHPW guinea pigs (20 animals/test group & 10 animals/control) were tested using the Guinea Pig Maximisation Test according to Magnusson and Kligman. The animals received intradermally 5% of the test item in physiological saline. One week after the intradermal induction, the animals received the second induction by applying the test item as a 25% suspension in physiological saline topically. Three weeks after the intradermal induction, the animals were challenged with a 25% suspension in physiological saline of the test item. The animals of the control group were not treated during the induction, but were treated once at each challenge. After the first challenge the treatment group showed erythema at the application site. Moreover, in the treatment groups scales of the skin were observed. In the control group no indication of skin sensitisation occurred.
During a second challenge the animals were treated with either 12% or 2.5% suspensions in physiological saline. During the re-challenge, erythema and encrustations of the skin were only observed in the treatment groups. No effects were observed in the control group animals. Therefore, based on the results obtained, the test item can be considered as a dermal sensitizer.
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