Registration Dossier
Registration Dossier
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EC number: 248-383-5 | CAS number: 27277-00-5
Endpoint summary
Administrative data
Description of key information
Additional information
Twelve healthy volunteers were orally dosed with 0.25, 0.5, 1.0, 2, 3, 4, and 8 mg. The emetic effects of the substance were studied. Based on the obtained results further studies were performed with a maximum dose of 2 mg. Of those who took 2 mg test substance (about 0.03 mg/kg) approximately 10% vomited and 60% complained of nausea. It can be concluded that the test substance can initiate emesis in humans at a dose of approximately 0.03 - 0.11 mg/kg bw.
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