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Physical & Chemical properties

Water solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1997-11-24 to 1997-12-29
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
Cited as Directive 92/69/EEC, A.6
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Water solubility:
835.2 g/L
Temp.:
20 °C
pH:
3.1
Details on results:
The water solubility of the test item as mean of all results was 835.2 ± 9.9 g/l at 20 °C ± 0.5 °C.

flask No.

del

pH value

measured HPLC peak area

1st injection [µV*s]

measured HPLC peak area

2nd injection [µV*s]

mean HPLC peak area [µV*s]

mean content of the measured solutions (per flask) [g/l]

mean water solubility [g/l]

1

a

3.0

159902.05

161505.92

160704.0

836.60

835.2

b

156251.30

159598.92

157925.1

2

a

3.0

158654.45

159862.11

159258.3

831.09

b

156421.81

158123.40

157272.6

3

a

3.3

160437.88

162709.39

161573.6

839.21

b

156802.58

159293.52

158048.1

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Conclusions:
A water solubility value of 835.2 ± 9.9 g/l was determined at 20 °C ± 0.5 °C and pH 3.1 in a reliable study conducted according to EC method A.6.
Executive summary:

A water solubility value of 835.2 ± 9.9 g/l was determined at 20 °C ± 0.5 °C and pH 3.1 in a reliable study conducted according to EC method A.6.

Description of key information

A water solubility value of 835.2 ± 9.9 g/l was determined at 20 °C ± 0.5 °C and pH 3.1 in a reliable study conducted according to EC method A.6.

Key value for chemical safety assessment

Water solubility:
835.2 g/L
at the temperature of:
20 °C

Additional information

At the test pH of 3.1, the test item is probably most stable.