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Diss Factsheets
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EC number: 277-923-2 | CAS number: 74563-64-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The skin irritation potential of the test substance was assessed according to OECD Test Guideline 404 and EU Method B.4. The mean value for erythema was ≥2.3 in all three rabbits and therefore the substance is classified as a skin irritant (Category 2).
The test substance was assessed for eye irritation potential according to OECD Test Guideline 405 and EU Method B.5. The test substance caused short-lasting corneal opacity with conjunctival reactions and therefore the substance is classified as an eye irritant (Category 2).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
The skin irritation potential of the test substance was assessed according to OECD Test Guideline 404 and EU method B.4 using a single topical application of 0.5 mL of the test substance to the intact skin of three rabbits for four hours under semi-occlusive dressing.
The average score (24 to 72 hours) for irritation was calculated to be 2.9 for erythema and 1.3 for oedema. The skin findings were not reversible in all animals within 14 days (study termination). Erythema and oedema were observed extending beyond the area of exposure.
The mean value for erythema was ≥2.3 in all three rabbits.
Eye irritation
The test substance was assessed for eye irritation potential according to OECD Test Guideline 405 and EU Method B.5. A single application of the neat test sample into the conjunctival sac of the rabbit eye caused short-lasting corneal opacity with conjunctival reactions which was reversed within two weeks. No staining of the cornea and sclera of the treated eyes by pigment or coloring of the test article were observed in all animals during the entire study period after test article application. Generally severe to slight corneal opacity was observed at (100%) in the left eye of the animals between 1 hour and 72 hours of it returned to generally slight diffuse corneal opacity between 24 and 72 hours after test article application.
Justification for classification or non-classification
Skin corrosion / irritation
Skin corrosion is defined as the production of irreversible damage to the skin following application of the test substance. Skin irritation is the production of reversible damage to the skin following application of the test substance. Substances can be allocated to one of two categories based on corrosive effects on the skin (Category 1) and irritating to the skin (Category 2) according to the Globally Harmonized Classification System and Regulation (EC) No. 1272/2008, relating to the Classification, Labelling and Packaging of Substances and Mixtures.
During in vivo testing, substances are classified as Category 2 irritants where a mean value of ≥2.3 is observed for erythema or for edema in at least two of the three animals tested from observations at 24, 48 and 72 hours after patch removal. If reactions are delayed, grades on three consecutive days after the onset of skin reactions also result in classification. Substances may be classified for skin irritation if inflammation persists to the end of the observation period in at least two animals.
The test substance was assessed for skin irritation potential and all three animals tested had scores for erythema≥2.3. The test substance is therefore classified as a skin irritant (Category 2).
Eye irritation
Serious eye damage is defined as the production of tissue damage in the eye, or serious physical decay or vision following application of the test substance to the anterior surface of the eye which is not fully reversible. Eye irritation means the production of changes in the eye following application of the test substance which is fully reversible. Substances can be allocated to one of two categories based on irreversible effects on the eye (Category 1) and irritating to the eye (Category 2) according to the Globally Harmonized Classification System and Regulation (EC) No. 1272/2008, relating to the Classification, Labelling and Packaging of Substances and Mixtures.
During in vivo testing, substances may be classified as irritating to eyes, if a corneal opacity score of ≥1 and / or an iritis score≥1 and / or conjunctival redness≥2 and or conjunctival edema (chemosis)≥2 in at least two of the three animals tested, calculated as the mean scores following grading at 24, 48 and 72 hours.
The test substance was assessed for eye irritation potential. Two of the three animals tested had a corneal opacity score ≥1. The test substance is therefore classified as an eye irritant (Category 2).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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