Registration Dossier
Registration Dossier
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EC number: 232-311-4 | CAS number: 8002-50-4 Extractives and their physically modified derivatives such as proteins, carbohydrates, lipids, nucleic acids, inorganic ions, etc. obtained from Brevoortia tyrannis.
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Principles of method if other than guideline:
- The estimation is based on ECOSAR v1.11. Two models are available, the estimation from the ECOSAR Class (Esters) and the Neutral Organic Structure Analysis Relationship (baseline toxicity).
- Specific details on test material used for the study:
- SMILES: CCCCCCCCCCCCCCCC(=O)(OCC(COC(=O)(CCCCCCCC=CCC=CCCCCC))OC(=O)(CCCCCCCCCCCCCCCCCCC)); MOL FOR: C57 H106 O6; MOL WT : 887.48; Log Kow: 23.506 (EPISuite Kowwin v1.68 Estimate); Wat Sol: 1.619E-020 (mg/L, EPISuite WSKowwin v1.43 Estimate); Calculation is based on the structure and / or properties of oils, menhaden.
- Analytical monitoring:
- not required
- Test type:
- other: calculation
- Total exposure duration:
- 96 h
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Details on results:
- Asterisk designates: Chemical may not be soluble enough to measure this predicted effect. If the effect level exceeds the water solubility by 10X, typically no effects at saturation (NES) are reported.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The lowest calculated EC50 to Green Algae for oils, menhaden is 9.6e-014 mg/L.
- Executive summary:
The short-term toxicity to green algae is calculated by ECOSAR v1.11. EC50 value for green algae, 96 h, is 9.6E-14 mg/L derived by calculation from ECOSAR class Esters. The calculated EC50 Neutral Organic Structure Analysis Relationship (baseline toxicity) for green algae is 4.01E-13 mg/L. Since the estimated partition coefficient (LogKow=23.506) is greater than the endpoint specific cut-off (LogKow=6.4), no effects at saturation are expected for this endpoint.
The EPA recommends that empirical measures provide better results. However, empirical studies have not been done, so that we adapt the prediction.
Reference
Description of key information
The short-term toxicity to green algae is calculated by ECOSAR v1.11. EC50 value for green algae, 96 h, is 9.6E-14 mg/L derived by calculation from ECOSAR class Esters. The calculated EC50 Neutral Organic Structure Analysis Relationship (baseline toxicity) for green algae is 4.01E-13 mg/L. Since the estimated partition coefficient (LogKow=23.506) is greater than the endpoint specific cut-off (LogKow=6.4), no effects at saturation are expected for this endpoint.
The EPA recommends that empirical measures provide better results. However, empirical studies have not been done, so that we adapt the prediction.
Key value for chemical safety assessment
Additional information
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