Registration Dossier
Registration Dossier
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EC number: 242-285-6 | CAS number: 18406-41-2
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- See attached justification
Cross-reference
- Reason / purpose for cross-reference:
- read-across source
Reference
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 02.02.2018 - 15.02.2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- At the start of the exposure and at renewal (0 and 24 hours), samples were taken after preparation of the test item concentrations and analyzed. At renewal and at the end of the exposure (24 and 48 hours), samples of the 24-hours old media were taken from the vessels.
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Origin: Institut Dr. Nowak
Breeder: Noack laboratorien GmbH, Käthe-Paulus-Str. 1, 31157, Sarstedt, Germany - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 262 mg CaCo3/L
- Test temperature:
- 18 - 22 °C
- pH:
- 7.42 - 7.52
- Dissolved oxygen:
- 4.49 - 6.87 mg/L
- Nominal and measured concentrations:
- Nominal loading levels (mg/L): 316, 100, 31.6, 10.0, 3.16, control
Measured concentrations at the start of exposure (0 h) (mg/L): 193, 50.9, 20.7, 3.69 1.33
Measured concentrations at renewal (24 h) (mg/L): 71.9, 52.8, 12.9, 4.62, 1.65 - Key result
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- 92.2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EL10
- Effect conc.:
- 83.2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EL100
- Effect conc.:
- 316 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- yes
Data source
Materials and methods
Test material
- Reference substance name:
- 3,3,6,6-tetramethoxy-2,7-dioxa-3,6-disilaoctane
- EC Number:
- 242-285-6
- EC Name:
- 3,3,6,6-tetramethoxy-2,7-dioxa-3,6-disilaoctane
- Cas Number:
- 18406-41-2
- Molecular formula:
- C8H22O6Si2
- IUPAC Name:
- 3,3,6,6-tetramethoxy-2,7-dioxa-3,6-disilaoctane
Constituent 1
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EL50
- Effect conc.:
- 92.2 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mobility
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
