Tetrachloro-μ-hydroxy(μ-methacrylato-O:O')dichromium

Endpoint summary

Description of key information

In an acute oral toxicicty study an oral LD50 of 6746 mg/kg bw was determined (UN GHS: no classification) (reference 7.2.1-1).

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

10 March 1980 - 28 July 1980

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Version / remarks:

1987 / At the time the study was performed no guideline for acute oral toxicity was established.

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Species:

rat

Strain:

other: ChR-CD

Sex:

male

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 33, 42, 44 and 49%
- Amount of vehicle: 4.13, 4.13, 4.47 and 4.22 mL

Doses:

6000, 7000, 7500 and 8000 mg/kg bw

No. of animals per sex per dose:

10 male rats per dose

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Other examinations performed: clinical signs, body weight

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

6 746 mg/kg bw

Based on:

test mat.

Mortality:

8000 mg/kg bw: 10/10; All deaths occurred within 3 days after dosing.
7500 mg/kg bw: 7/10; All deaths occurred within 5 days after dosing.
7000 mg/kg bw: 6/10; All deaths occurred within 3 days after dosing.
6000 mg/kg bw: 2/10; Both deaths occurred within 4 days after dosing.

Clinical signs:

other: 8000 mg/kg bw: Belly-to-cage posture, lacrimation, chromodacryorrhea, ataxia, eyes half-closed, salivation, piloerectlon, weakness, lethargy and slight weight loss after dosing. 7500 mg/kg bw: Belly-to-cage posture, lacrimation, chromodacryorrhea, eyes ha

Interpretation of results:

GHS criteria not met

Conclusions:

The oral LD50 was determined to be 6746 mg/kg bw.

Executive summary:

An oral LD50 test in rats was performed to determine the acut oral toxicity of the test item. A range-finding study using 1 rat/dose level was conducted to determine the initial dose level for the LD50 test. The LD50 test was performed with four dose groups (6000, 7000, 7500 and 8000 mg/kg bw) of ten young adult ChR-CD male rats. The test material, at an aqueous solution, was administered by intragastric intubation. Animals were weighed and observed during a 14-day recovery period and then sacrificed. The LD50 value was calculated from the mortality data using the method of D. J. Finney. The test item had a low toxicity when administered orally to young adult ChR-CD male rats in single doses. Clinical signs observed included belly-to-cage posture, lacrimation, chromodacryorrhea, eyes half-closed, salivation, weakness, lethargy and slight-moderate weight loss. Two animals died in the 6000 mg/kg bw dose group, six in the 7000 mg/kg bw dose group and seven animals were found dead in the 7500 mg/kg bw dose group. All animals of the 8000 mg/kg bw dose group died. All deaths occurred within 5 days after dosing. The oral LD50 was determined to be 6746 mg/kg bw.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LD50

Value:

6 746 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no study available

Additional information

Acute oral toxicity

An oral LD50 test in rats was performed to determine the acute oral toxicity of the test item. A range-finding study using 1 rat/dose level was conducted to determine the initial dose level for the LD50 test. The LD50 test was performed with four dose groups (6000, 7000, 7500 and 8000 mg/kg bw) of ten young adult ChR-CD male rats. The test material, at an aqueous solution, was administered by intragastric intubation. Animals were weighed and observed during a 14-day recovery period and then sacrificed. The LD50 value was calculated from the mortality data using the method of D. J. Finney. The test item had a low toxicity when administered orally to young adult ChR-CD male rats in single doses. Clinical signs observed included belly-to-cage posture, lacrimation, chromodacryorrhea, eyes half-closed, salivation, weakness, lethargy and slight-moderate weight loss. Two animals died in the 6000 mg/kg bw dose group, six in the 7000 mg/kg bw dose group and seven animals were found dead in the 7500 mg/kg bw dose group. All animals of the 8000 mg/kg bw dose group died. All deaths occurred within 5 days after dosing. The oral LD50 was determined to be 6746 mg/kg bw.

Justification for classification or non-classification

Classification, Labeling, and Packaging Regulation (EC) No 1272/2008

The available experimental test data are reliable and suitable for classification purposes under Regulation (EC) No 1272/2008. As a result the substance is not considered to be classified for acute oral toxicity under Regulation (EC) No 1272/2008, as amended for the tenth time in Regulation (EU) No 2017/776.