4-pyridylamine

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Data source

Reference

Reference Type:

publication

Title:

A Summary of the Acute Toxicity of 4-Aminopyridine to Birds and Mammals

Author:

EDWARD W. SCHAFER, JR., RONALD B. BRUNTON AND DONALD J. CUNNINGHAM

Year:

1973

Bibliographic source:

TOXICOLOGY AND APPLIED PHARMACOLOGY 26, 532-538 U.S. Bureau of Sport Fisheries and Wildlife, Wildlife Research Center, Denver, Colorado 80225

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Previously unpublished data from the Denver Wildlife Research Center (DWRC) were derived primarily by the po methods described by DeCino et al. (1966), Schafer (1972), and Schafer et aÍ. (1967). Other methods of oral administration included force-feeding synthetic pellets (Pan and Caslick, 1966) or treated grain. Dermal toxicity was determined by the method described by Schafer et al. (1969). All test animals were adults unless noted in the table. LD50 values and 95 % confidence limits were derived by the moving-point interpolation method described by Thompson (1948), Thompson and Weil (1952), and Weil (1952). The 4AP used was technical material of about 95% purity.
Methodology for other data can be found in the cited articles.

GLP compliance:

not specified

Test type:

other: not specified

Test material

Test material information

Constituent 1

Reference substance name:

4-pyridylamine

EC Number:

207-987-9

EC Name:

4-pyridylamine

Cas Number:

504-24-5

Molecular formula:

C5H6N2

IUPAC Name:

nickel

Test material form:

solid: particulate/powder

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

not specified

Control animals:

not specified

Results and discussion

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

20 mg/kg bw

Based on:

test mat.

Other findings:

4-Aminopyridine (4AP) is an acutely toxic substituted pyridine. In mammals, it produces the following sequence of clinical signs: hyperexcitability, salivation, tremors, muscular incoordination, clonic and tonic convulsions, cardiac or respiratory arrest, and death. At doses near the LD50, initial effects are usually noted in 10-15 min and death often occurs 15 min to 4 hr later. Occasionally, the tremor and/or convulsive stages are accompanied by audible vocalizations produced by strong, involuntary contractions of the diaphragm.

Applicant's summary and conclusion

Interpretation of results:

Category 2 based on GHS criteria

Conclusions:

LD50 (rat, oral): 20 mg/kg bw

Executive summary:

LD50 (rat, oral): 20 mg/kg bw (toxikology review: EPA TSCA Inventory)