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EC number: 276-851-9 | CAS number: 72797-41-2
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- (±)-7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide
- EC Number:
- 276-851-9
- EC Name:
- (±)-7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide
- Cas Number:
- 72797-41-2
- Molecular formula:
- C21H25ClN2O4S
- IUPAC Name:
- (±)-7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide
- Test material form:
- solid: crystalline
- Details on test material:
- White powder
Constituent 1
- Specific details on test material used for the study:
- Batch 562371/016 - purity : 100%
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Variety : StrausStrain : Berlin
Sex : female
Age: between 0 and 24 hours
Origin : Umweltbundesamt Berlin
Arrival of strain : Sept. 27th 2007
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- 24 and 48 hours
Test conditions
- Test temperature:
- 19.9 - 20.8°C
- pH:
- 7.5 to 7.7
- Dissolved oxygen:
- 8.8mg/L
- Nominal and measured concentrations:
- Nominal : 1/ 10/ 100 mg/L
- Details on test conditions:
- Before the study, there is a selection of daphnia. Replciates : Four vessels, each containing 20 mL test solution and five daphnia. Control : Four vessels, each containing 20 mL dilution water and five daphnia. Test vessels glass beakers, nominal volume 50 mL, tall shapeTemperature 20 +/- 2°C
- Reference substance (positive control):
- yes
- Remarks:
- K2Cr2O7
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Results with reference substance (positive control):
- The 24h-EC50 of potassium dichromate was tested in a current reference test. The value was determined as 1.3 mg/L, lying within the demanded range of 0.6 - 1.7 mg/L.
- Reported statistics and error estimates:
- All validity critera were met; For the estimation of the EC50 of the reference item, the fit showed sufficient statistical correspondence of the data with the dose-responsa equation
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- In accordance the guideline OECD 202, the following results could be determined for 1574 ACIDE :
48h and 24h NOEC = 100 mg/L
24h and 48h EC50i > 100 mg/L - Executive summary:
The experiment was performed using three concentrations ranging from 1 to 100 mg/L. Twenty daphnia were exposed to the test ite for 48 hours in a static test system. After 24 and 48 hours, the immobilised daphnia were counted.
The concentrations showed no toxicity. None of the animals were immobilised in the control.
The 24h-EC50 of potassium dichromate was tested in a current reference test. The value was determined as 1.3 mg/L, lying within the demanded range of 0.6 - 1.7 mg/L.
The following results could be determined for the 1574 ACIDE :
24 and 48h NOEC = 100mg/L
24 and 48h ECi50 > 100 mg/L
= 1 - 10 mg/L
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