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Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

22 February 2018 - 28 February 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

The study was conducted according to an internationally recognised method, and under GLP. The test substance is adequately characterised. Therefore full validation applies.

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Version / remarks:

1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Version / remarks:

2008

Deviations:

no

Principles of method if other than guideline:

Not applicable

GLP compliance:

yes (incl. QA statement)

Remarks:

Inspected on 4,5 and 6 July 2016/ Signed on 10 January 2017

Type of method:

differential scanning calorimetry

Key result

Boiling pt.:

189.3 °C

Atm. press.:

101.3 kPa

Decomposition:

no

First determination: (atmospheric pressure: 970.0 hPa)

Initial boiling point was observed at 187.6 °C (onset temperature of the first peak) and a corresponding mass loss is observed on the TG curve, showing that all the substance was evaporated at the end of the study.

The crucible was visually checked after the determination: by opening the crucible, no test item left in the crucible and no sign of decomposition was observed.

Second determination: (atmospheric pressure: 970.0 hPa)

Initial boiling point was observed at 187.6°C (onset temperature of the first peak) and a corresponding mass loss was observed on the TG curve, showing that all the substance was evaporated at the endof the study.

The crucible was visually checked after the determination: By opening the crucible, no test item left in the crucible and no sign of decomposition was observed.

In case of small pressure deviations the boiling temperature at standard pressure can be calculated following the equation of Sidney-Young.

T_n= T + (ƒ x ∆p)

With

T_n  = boiling point at 101.325 kPa in K

T    = measured boiling point in K

ƒ    = correction factor (tabulated value)

∆p  = (101.325 – p) kPa

P   = measured atmospheric pressure in kPa

The corrected values following Sidney-Young equation has been determined to be189.3 °C at 101.3 kPa (mean of 189.3 °C for the first determination and 189.3 °C for the second determination).

Conclusions:

The corrected values following Sidney-Young equation has been determined to be 189.3 °C at 101.3 kPa.

Executive summary:

The study was performed in order to determine the boiling point of test item according to OECD 103, resp. EU A.2, using the DSC method.

The initial boiling point of the test item has been determined to be 187.6°C at 970.0 hPa for both determinations. Corresponding mass loss was observed on the TG curve, showing that all the substance was evaporated at the end of the study.

The crucible was visually checked after the determination: by opening the crucible, no test item left in the crucible and no sign of decomposition was observed.

 

The corrected values following Sidney-Young equation has been determined to be189.3 °C at 101.3 kPa (mean of 189.3 °C for the first determination and 189.3 °C for the second determination).

Description of key information

The corrected values following Sidney-Young equation has been determined to be189.3 °C at 101.3 kPa (mean of 189.3 °C for the first determination and 189.3 °C for the second determination).

Additional information

Afully reliable experimental study, conducted according to OECD 102/ EU A1 guideline is available.

It is considered as a key study, and the result is retained as key data.