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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Link to relevant study record(s)

Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Insufficient details available to make a direct reliability assessment, however, inclusion in ECHA review article coupled with official OECD guideline being followed supportive of K2 reliability score.
Reason / purpose for cross-reference:
reference to same study
Qualifier:
according to guideline
Guideline:
OECD Guideline 211 (Daphnia magna Reproduction Test)
Deviations:
no
GLP compliance:
not specified
Test organisms (species):
Daphnia magna
Test type:
semi-static
Total exposure duration:
21 d
Duration:
21 d
Dose descriptor:
EC50
Effect conc.:
> 25 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks on result:
other: The overall average of measured concentrations of the test substance in the test solutions was 90 - 99 % of nominal.
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
>= 25 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks on result:
other: The overall average of measured concentrations of the test substance in the test solutions was 90 - 99 % of nominal.
Validity criteria fulfilled:
yes
Conclusions:
The 21-day EC50 value was considered to be higher than 25 mg/L.
The 21-day NOEC value was considered to be or higher than 25 mg/L.

Description of key information

A long-term toxicity study with daphnia is available. In the study (Pawlowski, 2004) with Daphnia magna the NOEC ≥ 25 mg/L.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
25 mg/L

Additional information

A long term toxicity study with daphnia is available indicating a NOEC ≥ 25 mg/L (nominal with measured concentrations within desired ranges). The study (Pawlowski, 2004) was a semi-static 21 day study according to OECD 211.