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EC number: 630-523-5 | CAS number: 160611-47-2
Glucan 1,4-alpha-maltohydrolase was tested for skin and eye irritation.
- Maltogen amylase was not irritating and can be classified as a ‘non irritant’ to the rabbit eye.
- Maltogen amylase was not irritating and can be classified as a ‘non irritant’ to the rabbit skin.
The acute dermal irritant effect of maltogen amylase was investigated according to the method recommended in the OECD Guideline No 404, “Acute Dermal Irritation/Corrosion”. The study was conducted in accordance with GLP. The study was performed on six (3 males and 3 females) New Zealand White rabbits. They were each exposed to 0.5 mL of the undiluted liquid test item applied under occlusive conditions of each of the closely-clipped intact and abraded test sites on the back of the animals. After a 4-hour exposure period, the test item was removed from the test site and the skin was examined after 30 minutes, 24 h, 48 h and 72 h.
No reactions were observed at the intact skin sites after contact with maltogen amylase, batch PPY 1624, for 4 hours. At the abraded sites very slight redness was observed in 4 rabbits and very slight edema (at 0.5 hour only) in 2 rabbits. All reactions had disappeared at the 72 hours reading.
Maltogen amylase (IUBMB 18.104.22.168) is classified as non-irritant to skin.
Maltogen amylase, was instilled in the conjunctival sac of 6 rabbits in order to examine the irritation potential to the eyes. The untreated eye served as control. The ocular reactions were recorded at 1, 24, 48, 72 hours and 7 days after instillation according to the specified guideline.
No corneal opacity or iris reactions were noted at any time during the test. Only very slight redness of the conjunctiva of animal #20 at 24 hours was observed, however, this was fully reversible within 48 hours. All signs were reversible, and no reactions were seen after 48 or 72 hours, or after 7 days.
In conclusion, maltogen amylase can be classified as a 'non-irritant' to the eyes.
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