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EC number: 205-324-8 | CAS number: 138-32-9
The statistically significant increase in frequency of micronuclei is considered to be of no biological relevance for the following reasons:
- The frequency of micronuclei at this sampling time point (0.18%) is not above the frequency of micronuclei of controls generally observed in this test laboratory (0.07 - 0.22%). The statistical significance in this case is caused by the low frequency of micronuclei in the control group (0.02%) which deviates downwards from the so far observed frequencies for controls. After addition of male and female animals of sampling time point 72 h into one group there is no more a statistically significant difference.
- A delayed effect based on slow excretion is improbable for sodium cumenesulphonate as sulphonic acids in general are readily absorbed and do not show any tendency for accumulation. But this kind of detention is regarded as prerequisite to explain based on the kinetic of erythrocyte maturation an impact on micronuclei frequency at sampling time point of 72 hours.
The results of the positive control affirm the sensitivity of the mouse strain to mutagenic substances.The frequency of micronuclei in polychromatic erythrocytes was considerably increased compared to the control group.
Table 1: Results of in vivo micronucleus test for male animals (mean ± standard deviation)
*p < 0.05
Table 2: Results of in vivo micronucleus test for female animal (mean ± standard deviation)
Table 3: Results of in vivo micronucleus test for male + female animals (mean ± standard deviation)
* p < 0.05
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