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EC number: 915-672-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
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- Additional physico-chemical information
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- Endpoint summary
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
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- Endocrine disrupter testing in aquatic vertebrates – in vivo
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- Additional toxicological data

Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- The hypothesis for a read-across approach to data from TMPTA is the similarity of the chemical structures.Both the target substance (T) and TMPTA are triacryaltes.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- ISO 8192 (Water quality - Test for inhibition of oxygen consumption by activated sludge for carbonaceous and ammonium oxidation)
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 301C
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Only specified for the study following the OECD 301C Guideline
- Key result
- Duration:
- 30 min
- Dose descriptor:
- other: EC20
- Effect conc.:
- 625 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: TMPTA
- Basis for effect:
- inhibition of total respiration
- Remarks:
- ISO 8192
- Conclusions:
- Trimethylolpropantriacrylate was tested for respiratory sludge inhibition according to guideline ISO/DIS 8192 Part B. The inoculum was derived from the local municipal STP Lambsheim. The EC20 was determined to be after 30 min EC20 = 625 mg/l.
The target is primarily a mixture of trimethylolpropantriacrylate and dimethylolpropantriacrylate, and these two acrylates are assessed to show the same level of environmental toxicity to aquatic organism - the triacrylate compound being only very slightly more toxic than the diacrylate (QSAR calculations confirm this). Therefore, it is asssessed valid to set to toxicity to microorganism of a mixture of trimethylolpropantriacrylate and dimethylolpropantriacrylate to the toxicity of trimethylolpropantriacrylate.
Based on the test result an inhibition of the respiration and biodegradation activities of mircroorganisms within an STP is not expected. - Executive summary:
Trimethylolpropantriacrylate was tested for respiratory sludge inhibition according to guideline ISO/DIS 8192 Part B. The inoculum was derived from the local municipal STP Lambsheim. The EC20 was determined to be after 30 min EC20 = 625 mg/l.
The target is primarily a mixture of trimethylolpropantriacrylate and dimethylolpropantriacrylate, and these two acrylates are assessed to show the same level of environmental toxicity to aquatic organism - the triacrylate compound being only very slightly more toxic than the diacrylate (QSAR calculations confirm this). Therefore, it is asssessed valid to set to toxicity to microorganism of a mixture of trimethylolpropantriacrylate and dimethylolpropantriacrylate to the toxicity of trimethylolpropantriacrylate.
Based on the test result an inhibition of the respiration and biodegradation activities of mircroorganisms within an STP is not expected.
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988-05-16
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
- Qualifier:
- according to guideline
- Guideline:
- ISO 8192 (Water quality - Test for inhibition of oxygen consumption by activated sludge for carbonaceous and ammonium oxidation)
- Deviations:
- no
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Test organisms (species):
- activated sludge, domestic
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 30 min
- Key result
- Duration:
- 30 min
- Dose descriptor:
- other: EC20
- Effect conc.:
- 625 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test substance cause after 30 min an EC20= 625 mg/l
- Executive summary:
Trimethylolpropantriacrylat was tested for respiratory sludge inhibition according to guideline ISO/DIS 8192 Part B. The inoculum was derived from the local municipal STP Lambsheim. The EC20 was determined to be after 30 min EC20 = 625 mg/l.
Based on the test result an inhibition of the respiration and biodegradation activities of mircroorganisms within an STP is not expected.
Referenceopen allclose all
EC20 after 30 min EC20 = 625 mg/l
highest test conc. causing < 20 % respiratory inhibition: 467.6 mg/l
inoculum: municipal STP: Lambsheim
Description of key information
The substance ( Trimethylolpropantriacrylate) was tested for respiratory sludge inhibition according to guideline ISO/DIS 8192 Part B. The study was assessed to be reliable with restrictions and considereed as key study. The inoculum was derived from the local municipal STP Lambsheim. The EC20 was determined to be after 30 min EC20 = 625 mg/l. This concentration is also considered to be the EC50.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 625 mg/L
Additional information
The substance was tested for respiratory sludge inhibition according to guideline ISO/DIS 8192 Part B. The study was assessed to be reliable with restrictions and considereed as key study. The inoculum was derived from the local municipal STP Lambsheim. The EC20 was determined to be after 30 min EC20 = 625 mg/l. This concentration is also considered to be the EC50.
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