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EC number: 606-541-4 | CAS number: 2037-95-8
The objective of the study was to evaluate 3,4-dihydro-2,4-dioxo-1,3-2h-benzoxazine for its ability to generate acute toxic effects on the mobility of Daphnia magna during an exposure period of 48 hours and, if possible, to determine the EC50at 24 and 48 hours of exposure.
The study procedures described in this report were based on the OECD guideline No. 202, 2004.
The batch of 3,4-dihydro-2,4-dioxo-1,3-2h-benzoxazine tested was a white powder with a purity of approximately 99% which was completely soluble in test medium at the concentrations tested.
A combined limit/range-finding test was performed. Twenty daphnids per group (5 per replicate, quadruplicate) were exposed to an untreated control and to a nominal concentration of 100 mg/L, in a limit test. In addition ten daphnids per group (5 per replicate, duplicate) were exposed to nominally 0.10, 1.0 and 10 mg/L in the combined range-finding test. The total exposure period was 48 hours and samples for analytical confirmation of exposure concentrations were taken at the start and at the end of the test.
Samples taken from the limit concentration were analysed. The measured concentration at the start of the test was 99 mg/L and had decreased to 79% relative to nominal at the end of the test. Based on these results, effect parameters were expressed in terms of the average exposure concentration, calculated to be 88 mg/L.
No immobility was observed in the control and at any of the test concentrations throughout the exposure period.
The study met the acceptability criteria prescribed by the study plan and was considered valid.
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