Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report Date:
2016

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: pretest OECD 105
Version / remarks:
solubility of the test item in water & n-octanol was determined separately by visual assessment . The log Pow was calculated from these two values.
Deviations:
not applicable
GLP compliance:
yes (incl. certificate)
Type of method:
estimation method (solubility ratio)
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
< -1.7
Temp.:
21.1 °C
Remarks on result:
other: no information on pH available

Applicant's summary and conclusion

Conclusions:
The solubility of the test item in water and n-octanol was determined separately by visual assessment according to the pretest from OECD 105 (GLP) and the log Pow was calculated from these two values. Test procedure is in accordance with generally accepted scientific standards and described in sufficient detail and therefore, reliability of Klimisch 1 has been assigned. The log Pow of the test item was determined to be ≤ - 1.7 at 21.1 °C.
Executive summary:

For the test item the partition coefficient was not determined according to the Guidelines OECD 107 or 117 because a certain surface activity was suspected, but was calculated based on experimental data as follows: The solubility of the test item in water and n-octanol was determined separately by visual assessment according to the pretest from OECD 105 (GLP). The log Pow was calculated from these two values; the log Pow of the test item was determined to be ≤ - 1.7 at 21.1 °C.