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EC number: 905-357-4 | CAS number: -
In a Local Lymph Node Assay (BrdU-ELISA), the skin sensitisation potential of the substance was tested according to OECD TG 442B under GLP. Per concentration, 5 female mice were used. Skin sensitization potential was evaluated by ear thickness measurements. Cellular proliferations and SI were determined. In the first set, at 25, 50 and 100%, SI values were 1.78, 2.15 and 1.70, respectively. In the second set, at 1, 5 and 10%, SI values were 1.22, 1.10 and 1.40, respectively. Negative and positive controls were included and all acceptability criteria were met (SI values positive controls: 3.10 and 4.32). These results show that the substance could elicit a SI ≥ 1.6. An EC1.6 value of 26.4% was calculated. Based on the results, the substance is considered a skin sensitiser 1B.
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