Registration Dossier
Registration Dossier
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EC number: 289-147-1 | CAS number: 86088-80-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 12 Nov - 12 Dec 1997
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Lack of study details, amount and concentration of test substance applied not specified and analytical purity of test substance not specified
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Lack of study details, amount and concentration of test substance applied is not specified and analytical purity of test substance not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Isooctadecanoic acid, mono-, di- and triesters with triglycerol
- EC Number:
- 291-548-1
- EC Name:
- Isooctadecanoic acid, mono-, di- and triesters with triglycerol
- Cas Number:
- 90431-25-7
- IUPAC Name:
- 90431-25-7
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- other: not required, untreated sites of the same animal served as control
- Duration of treatment / exposure:
- not specified (4 hours according to OECD 404 which is given as Method)
- Observation period:
- 72 hours
Reading time points: 1, 24, 48 and 72 h - Number of animals:
- 3
- Details on study design:
- SCORING SYSTEM: Draize Scoring System
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- out of all 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- out of all 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: reversibility: not applicable
- Irritant / corrosive response data:
- Only slight erythema was seen on skin of all three animals tested starting 1 hour following application and was fully reversible within 72 hours following application.
- Other effects:
- None
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/ EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008
- Conclusions:
- CLP: not classified
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