2-[(5A,7A)-17-(CYCLOPROPYLMETHYL)-3,6-DIMETHOXY-18,19-DIHYDRO-4,5-EPOXY-6,14-ETHENOMORPHINAN-7-YL]-3,3-DIMETHYLBUTAN-2-OL

Flammability

Administrative data

Endpoint:

flammable solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2003

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Although the study was not performed according to an OECD or EC guideline, the used methodology is adequate and sufficient to conclude on the 'flammability solids' endpoint. However, no information on purity of the substance is reported.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2003

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method A.10 (Flammability (Solids))

Deviations:

yes

Remarks:

: In the EC guidelinea hot flame from a gas burner (minimum diameter 5 mm) is prescribed. In this test a hot platinum wire at ca. 1000 deg C is used.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

(2S)-2-[(1S,2R,6S,14R,15R,16R)-3-(cyclopropylmethyl)-11,15-dimethoxy-13-oxa-3-azahexacyclo[13.2.2.1²,⁸.0¹,⁶.0⁶,¹⁴.0⁷,¹²]icosa-7,9,11-trien-16-yl]-3,3-dimethylbutan-2-ol

Cas Number:

16524-65-5

Molecular formula:

C30H43NO4

IUPAC Name:

(2S)-2-[(1S,2R,6S,14R,15R,16R)-3-(cyclopropylmethyl)-11,15-dimethoxy-13-oxa-3-azahexacyclo[13.2.2.1²,⁸.0¹,⁶.0⁶,¹⁴.0⁷,¹²]icosa-7,9,11-trien-16-yl]-3,3-dimethylbutan-2-ol

Test material form:

solid: particulate/powder

Details on test material:

- Name of test material (as cited in study report): JNJ-18163678-AAA (T002713)
- Physical state: solid (powder)
- Appearance: White powder

Results and discussion

Flammable solids

Key result

Test procedure:

burning rate test: preliminary screening test

Remarks on result:

substance does not ignite and propagate combustion either by burning with flame or smouldering along 200 mm of the powder train within the 2 minutes test period

Any other information on results incl. tables

Results: Not readily combustible substance of Division 4.1. Interpretation of the results: Powders are to be considered as readily combustible when the time of burning in any one of the 6 tests carried out according to the test procedure decscribed is less than 45 seconds or the burning rate is greater than 2.2 mm/s. Powders of metals or metal alloys are considered to be readily combustible when they can ignited and the flame on the reaction spreads over the whole sample in 10 minutes or less. Materials, others than metal powders are classified as UN/DOT Division 4.1 (Flammable Solids) when the time of burning of one or more of the test runs is less than 45 seconds. Packaging Group II is assigned if the burning time is less than 45 seconds and the flame passes the wetted zone. Packaging II is assigned to powders of metal or metal alloys if the zone of reaction spreads over the whole lenght of the sample in five minutes or less. Packaging III is assigned to materials other than metal powders, if the burning time is less than 45 seconds and the wetted zone stops the flame propagation for at least 4 minutes. Packaging Group III is asigned to metal powders if rection spreads over the whole lenght of the sample in more than five minutes but not more than ten minutes.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

Not readily combustible substance of Division 4.1