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EC number: 290-140-0
CAS number: 90082-51-2
Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Pelargonium graveolens, Geraniaceae.
Skin sensitisation (OECD TG 429): Sensitising (EC3 of 38%)
The skin sensitisation potential of the Geranium oil has been tested
according to the OECD TG 429 (Local Lymph Node Assay) guideline. At
5, 10, 25, 50, and 100% the substance showed SI values of 0.69,
0.91, 1.04, 4.95 and 2.23, respectively. No cutaneous reactions and
noteworthy increase in ear thickness were observed at any tested
In the treated groups, a positive lymphoproliferative response (SI >
3) was noted at the concentration of 50%, without clear evidence of
a dose-response relationship. Based interpolation between the 25 and
50% dose, the test item was found to have an EC3 value of 38% and is
considered to be a sensitiser under the conditions of the test.
Based on the available data, the substance is classified as a skin
sensitiser (Skin Sens. 1B / H317) in accordance with the criteria
outlined in EU CLP (EC no 1272/2008 and its amendments).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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