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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

explosiveness, other
Type of information:
other: Expert assessment
Adequacy of study:
key study
Study period:
August 21, 2017
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: An assessment was performed based on the molecular structure and functionality of 2-(2-methylpropoxy)ethanol in conjunction with relevant regulation.
no guideline followed
Principles of method if other than guideline:
An assessment was undertaken to determine the explosive potential of 2-(2-methylpropoxy)ethanol and the raw materials required in its manufacture. Experimental data and literature relating to the molecular structure (functionality) of the registration substance was reviewed, where available, in conjunction with relevant REACH Regulation (EC) No. 1907/2006 and CLP Regulation (EC) No. 1272/2008. Particular focus was given to a number of structural motifs that are associated with explosive behaviour (Appendix 6, UN Recommendations on the Transport of Dangerous Goods: Manual of Tests and Criteria, 6th Ed.).
GLP compliance:
Key result
Test series:
other: Not applicable
other: Expert assessment of available information
other: Molecular structure
result is considered "-" (negative)
Remarks on result:
other: 2-(2-Methylpropoxy)ethanol does not possess explosive properties

Table 1. Elements that are associated with explosive properties (Appendix 6, UN Recommendations on the Transport of Dangerous Goods: Manual of Tests and Criteria, 6th Ed.).

Functional group (examples) Conclusion
C-C unsaturation (acetylenes, acetylides, 1,2-dienes) Not present
C-metal and N-metal (Grignard reagents, organo-lithium compounds) Not present
Contiguous N atoms (azides, aliphatic azo compounds, diazonium salts, hydrazines Not present
Contiguous O atoms (peroxides, ozonides) Not present
N-O (hydroxylamines, nitrates, nitro compounds, nitroso compounds, N-oxides) Not present
N-halogen (chloramines, fluoroamines) Not present
O-halogen (chlorates, perchlorates) Not present
Interpretation of results:
GHS criteria not met
2-(2-Methylpropoxy)ethanol does not possess any chemical functionality that is typically associated with explosive behaviour and, therefore, does not require classification for explosiveness.
Executive summary:

An assessment was undertaken to determine the explosive potential of 2-(2 -methylpropoxy)ethanol and its raw materials based on their molecular structure (functionality) and a review of available literature and experimental data. A number of structural motifs can be linked to explosive behaviour in organic material, as identified in Appendix 6, UN Recommendations on the Transport of Dangerous Goods: Manual of Tests and Criteria, 6th Ed. The REACH Regulation (EC) No. 1907/2006, Section 7.11 and CLP Regulation (EC) No. 1272/2008, Section were referred to in order to implement a screening procedure. Structural features commonly associated with explosive behaviour were not identified in 2-(2 -methylpropoxy)ethanol and, therefore, the registration substance is not believed to be explosive. The raw components did not contain halogens, nitrogen, or metals, and these elements were not present in the final product. In addition, oxygen was identified but this was not contained within a chemical group that is considered to be linked with explosiveness. Hazard classification of 2-(2-methylpropoxy)ethanol is subsequently not required and further testing is not necessary (Column II of REACH Annex VII).

Description of key information

An expert assessment was undertaken to review the explosiveness of 2-(2-methylpropoxy)ethanol. As a result of the substance not containing any structural features commonly associated with explosive behaviour, it was concluded that the substance is not an explosive. 2-(2-methylpropoxy)ethanol subsequently does not require classification (CLP Regulation (EC) No. 1272/2008).

Key value for chemical safety assessment

non explosive

Additional information

The endpoint conclusion determined for explosiveness is believed to be the key value and has been assigned a Klimisch score of 2 (reliable with restrictions) given that it was obtained from a weight of evidence approach.

Justification for classification or non-classification