Registration Dossier
Registration Dossier
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EC number: 202-700-3 | CAS number: 98-79-3
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Description of key information
After reviewing the available literature, it is believed that there is sufficient information on pidolic acid to support the case for waiving toxicokinetic studies.
It is concluded that after absorption, pidolic acid is likely to be incorporated into normal metabolism either to be terminally oxidized or to produce glutathione (an essential component of detoxification mechanisms from bacteria to humans) and glutamate (an amino acid and an essential part of the normal diet). The absorption, distribution, metabolism and excretion of such compounds is well understood in mammals and therefore further toxicokinetic studies in animals cannot be considered necessary or an appropriate use of animals.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 70
- Absorption rate - dermal (%):
- 20
- Absorption rate - inhalation (%):
- 100
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
