Pidolic acid

Appearance / physical state / colour

Link to relevant study record(s)

Reference

Endpoint:

appearance / physical state / colour

Type of information:

experimental study

Adequacy of study:

key study

Study period:

The experimental work associated with this study was carried out between 11 November 2016 and 22 March 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Qualifier:

no guideline followed

Principles of method if other than guideline:

Visual inspection and weighing of packs, pre storage and post storage.

GLP compliance:

yes (incl. QA statement)

Specific details on test material used for the study:

Test substances: (2S)-5-oxopyrrolidine-2-carboxylic acid Technical Materials
Acid Source: (2S)-5-oxopyrrolidine-2-carboxylic acid (Acid Source)
Salt Source: (2S)-5-oxopyrrolidine-2-carboxylic acid (Potassium Salt)
Received on: 8th November 2016
DNAL Sample Numbers: DNA3730/1-2
Reference Standard: (S)-(-)-2-Pyrrolidinone-5-carboxylic acid reference standard
Received on: 6th January 2017

Physical state at 20°C and 1013 hPa:

solid

Remarks:

DNA3730/1 crystalline powder solid, DNA3730/2 uniform clear liquid

Key result

Form:

solid: particulate/powder

Remarks:

DNA3730/1 granules below 1 mm in diameter

Colour:

white

Odour:

odourless

Form:

liquid

Remarks:

DNA3730/2 liquid with no sign of seperation

Colour:

clear

Odour:

odourless

Appearance Pre Storage Results

Analysis/Test	Method	Pre Storage Sample DNA3730/1 (Acid Source)
Appearance	Visual inspection and weighing of packs.	Stability of Packaging Sample DNA3730/l (Acid Source) was contained in a transparent plastic bag 30cm x 20cm. The plastic bag was heat sealed and contained another plastic bag sealed with a cable tie. There were no signs of any leaks. Appearance Sample DNA3730/l was a uniform white crystalline powder with granules below Imm in diameter. The sample was free flowing with no signs of clumping and no compaction. The sample had a no discernible odour. Weights (Prior to Storage): DNA3730/l: 532.84g DNA3730/1 Sub Sample: l 7.0397g

Analysis/Test	Method	Pre Storage Sample DNA3730/2 (Salt Source)
Appearance	Visual inspection and weighing of packs.	Stability of Packaging Sample DNA3730/2 (Salt Source) was contained in a 2L brown plastic bottle 26cm x 22.5cm. The bottle had a brown screw-top lid and an aperture size of 3 .5cm. The bottle had no external seal and a plastic stopper internal seal. The bottle showed no signs of leaks or panelling. Appearance Sample DNA3730/2 was a uniform clear liquid. The sample was free flowing with no signs of separation into cream or oil and had no sign of sedimentation, claying or of suspended solids. The sample had a no discernible odour. Weights (Prior to Storage): DNA3730/2: 2169.90g DNA3730/2 Sub Sample: 21.1164g

Appearance Post Storage Results

Analysis/Test	Method	Post Storage Sample DNA3730/1 and DNA3730/2
Appearance	Visual inspection and weighing of packs.	Stability of Packaging Sample DNA3730/1 was subsampled into a 5mL glass vial for 2 weeks accelerated storage at 54 °C. Sample DNA3730/2 was subsampled into a 5mL glass vial for 2 weeks accelerated storage at 54 °C. Appearance Sample DNA3730/1 was a uniform white crystalline powder with granules below 1 mm in diameter. The sample was free flowing with no signs of clumping and no compaction. The sample had a no discernible odour. Sample DNA3730/2 was a uniform clear liquid. The sample was free flowing with no signs of separation into cream or oil and had no sign of sedimentation, claying or of suspended solids. The sample had a no discernible odour. Weights (Post Storage): DNA3730/1 Sub Sample: l 7.0397g Prior to Storage DNA3730/1 Sub Sample: 16.9878g Post Accelerated Storage DNA3730/2 Sub Sample: 21. l l 64g Prior to Storage DNA3730/2 Sub Sample: 21.0657g Post Accelerated Storage

No significant deviation was recorded in this part of the study.

Acid Source

The samples of (2S)-5-oxopyrrolidine-2-carboxylic acid Technical Material arrived in good condition with no evidence of any leaks. The appearance of Sample (DNA3730/l) Acid Source appeared unchanged post accelerated storage at 54°C ±2°C for 2 weeks

from the pre storage sample.

Salt Source

The samples of (2S)-5-oxopyrrolidine-2-carboxylic acid Technical Material arrived in good condition with no evidence of any leaks or panelling. The appearance of Sample (DNA3730/2) Salt Source appeared unchanged post accelerated storage at 54°C ±2°C for 2 weeks from the pre storage sample.

Conclusions:

White crystalline solid.

Description of key information

Pidolic acid is white crystalline solid.

Key value for chemical safety assessment

Physical state at 20°C and 1013 hPa:

solid

Form:

solid: crystalline

Colour:

white

Colour intensity:

light