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Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Referenceopen allclose all

Endpoint:
acute toxicity: oral
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Study period:
1976
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data considered reliable by ECHA.
Qualifier:
no guideline available
Principles of method if other than guideline:
Unknown
GLP compliance:
not specified
Details on oral exposure:
LD50 Rat oral 3650mg/kg.Source Food and Cosmetics Toxicology.Vol. 14,Pg.875,1976
Dose descriptor:
LD50
Effect level:
3 650 mg/kg bw
Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 Rat oral 3650mg/kg.The substance is classified as a category 5 GHS regulation.
Endpoint:
acute toxicity: oral
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Study period:
2008
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data considered reliable by ECHA.
Qualifier:
no guideline available
Principles of method if other than guideline:
Unknown
GLP compliance:
not specified
Details on oral exposure:
LD50 Rat oral 2790 mg/kg (2440-3180, 95% CL) /From table/[Organization for Economic Cooperation and Development; Screening Information Data Set for LINALOOL (78-70-6) p.13 (March 2002). Available from, as of July 15, 2008: http://www.chem.unep.ch/irptc/sids/OECDSIDS/sidspub.html] **PEER REVIEWED**
Dose descriptor:
LD50
Effect level:
2 790 mg/kg bw
Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 Rat oral 2790 mg/kg. The substance is classified as a category 5 GHS regulation.
Endpoint:
acute toxicity: oral
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Study period:
2006
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data considered reliable by ECHA.
Qualifier:
no guideline available
Principles of method if other than guideline:
Unknown
GLP compliance:
not specified
Details on test animals and environmental conditions:
LD50 Rat oral 4750 mg/kg [O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ:Merck and Co., Inc., 2006., p. 464] **PEER REVIEWED**
Dose descriptor:
LD50
Effect level:
ca. 4 750 mg/kg bw
Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The LD50 rat oral 4750 mg/kg body weight. The substance is classified as a category 5 GHS regulation.
Endpoint:
acute toxicity: oral
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Study period:
2000
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data considered reliable by ECHA.
Qualifier:
no guideline available
Principles of method if other than guideline:
Unknown
GLP compliance:
not specified
Details on oral exposure:
LD50 Mouse oral 640 mg/kg [Lewis, R.J. Sr. (ed) Sax's Dangerous Properties of Industrial Materials. 11th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2004., p. 3463] **PEER REVIEWED**
LD50 Rat oral 980 mg/kg [Lewis, R.J. Sr. (ed) Sax's Dangerous Properties of Industrial Materials. 11th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2004., p. 3463] **PEER REVIEWED**
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 650 mg/kg bw
Based on:
not specified
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 980 mg/kg bw
Based on:
not specified
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
LD50 rat oral 980 mg/kg body weight
LD50 mouse oral 640 mg/kg body weight.
Endpoint:
acute toxicity: oral
Type of information:
other: bibliography
Adequacy of study:
other information
Study period:
1973
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data considered reliable by ECHA.
Qualifier:
no guideline available
GLP compliance:
not specified
Species:
rat
Strain:
not specified
Sex:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
>= 3 750 - <= 5 670 mg/kg bw
Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The acute oral LD50 value in rats was reported as 4700 mg/kg (3570-5670 mg/kg).
The classification of thym oil red is category 5.
Endpoint:
acute toxicity: oral
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Qualifier:
according to
Guideline:
other: section 3.1.3.6.2.3 of 1272/2008 EC regulation
Principles of method if other than guideline:
Based on a weight of evidence approach, the acute toxicity oral of this UVCB substance can be estimated using adequate toxicity data of major constituents, greater than 4.55% in the mixture.
4 constituents were considered, representing 72.75% of the mixture. These data are summarized in the table below.
The acute toxicity oral was estimated using the following additivity formula, as recommended in the Regulation (EC) No 1272/2008 (CLP) part 3.1.3.6.2.3.:
100-(∑ Ci unkown if > 10 %) / ETA mix = ∑ (Ci / ETAi)Where,Ci = concentration of component i (weight percentage); i = the individual ingredient from 1 to n ; n = the number of ingredients ; ATE i = Acute Toxicity Estimate of ingredient i.
Sex:
not specified
Dose descriptor:
approximate LD50
Effect level:
ca. 1 602 mg/kg bw
Based on:
other: calculation according to additivity formula of CLP regulation section 3.1.3.6.2.3.
Interpretation of results:
GHS criteria not met
Conclusions:
With a LD50 oral estimated at 1602 mg/kg, the thyme oil is classified H302 according to CLP criteria and GHS criteria.
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1979
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Monograph used by the fragrance industry.
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
RIFM protocol in 1973
GLP compliance:
no
Species:
rat
Key result
Sex:
not specified
Dose descriptor:
approximate LD50
Effect level:
> 3 750 - < 5 670 mg/kg bw
Based on:
not specified
Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The acute oral LD50 value in rats was reported 4.70 g/kg (Moreno, 1973).
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
discriminating dose
Value:
980 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification