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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From July 2016 to January 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Batch No.of test material: 24/02/2016
- Expiration date of the lot/batch: July 2021
- Purity test date: July 2016

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: In darkness at room temperature

Key result
Water solubility:
37.9 mg/L
Conc. based on:
test mat. (total fraction)
Loading of aqueous phase:
200 g/L
Incubation duration:
>= 24 - <= 72 h
Temp.:
20 °C
pH:
ca. 3.7
Water solubility:
28.6 mg/L
Conc. based on:
act. ingr.
Loading of aqueous phase:
200 g/L
Incubation duration:
>= 24 - <= 72 h
Temp.:
20 °C
pH:
ca. 3.7

Preliminary test:

Table 1: preliminary test results

Weight

of test item

(g)

Volume

of water

(mL)

Solubility*

(g/L)

0.11840

0.1

N

/

0.11840 

0.5

N

/

0.11840 

1

N

/

0.11840 

2

N

/

0.05171

10

Y

50-10

* Solubility: No: Undissolved material was visually observable in the test solution

Yes: No undissolved material was visually observable in the test solution

Main test:

Table 2: Solubility in water

 

 

 

 

Conc.

Dilution

factor

Final concentration

1-chloro-2-(difluoromethoxy)-1,1,2,3,3,3,-hexafluoro-propane

Final conc.

in

SOLVENT N1

(mg/L)

(mg/L)

(mg/L)

C

Df

Cf

Cf1

After 24h

140.2

0.2

28.04

37.09

156.4

0.2

31.28

41.38

After 48h

123.5

0.2

24.71

32.68

145.0

0.2

29.00

38.36

After 72h

130.2

0.2

26.03

34.43

163.9

0.2

32.78

43.36

 

Mean

28.6

37.9

SD

3.1

4.1

RSD(%)

10.7

10.7

Conclusions:
The solubility in water of "Reaction mass of 1-chloro-2-(difluoromethoxy)-1,1,2,3,3,3-hexafluoro-propane and 2-difluoromethoxy-1,1,1,2,3,3,3-eptafluoro-propane " performed at 20 0 °C ± 2.0 °C was 28.6 mg/L.
The solubility in water of the test item expressed as SOLVENT N1 at 20 0 °C ± 2.0 °C was 37.9 mg/L.
The pH of the aqueous samples was 3.66 to 3.83.
Executive summary:

The water solubility of the test item was determined with Shake flask method according to recognized guidelines (OECD Guideline 105 and EU Method A.6 a) and GLP. No deviation from the guideline was observed during the study.

The solubility in water of "Reaction mass of 1-chloro-2-(difluoromethoxy)-1,1,2,3,3,3-hexafluoro-propane and 2-difluoromethoxy-1,1,1,2,3,3,3-eptafluoro-propane "

performed at 20 0 °C ± 2.0 °C was 28.6 mg/L.

The solubility in water of the test item expressed as SOLVENT N1 at 20 0 °C ± 2.0 °C was 37.9 mg/L.

The pH of the aqueous samples was 3.66 to 3.83

Description of key information

One reliable key study (Klimisch 1) is available.

The water solubility of the test item was determined with Shake flask method according to recognized guidelines (OECD Guideline 105 and EU Method A.6 a) and GLP. No deviations from the guideline were observed during the study.

The solubility in water of "Reaction mass of 1-chloro-2-(difluoromethoxy)-1,1,2,3,3,3-hexafluoro-propane and 2-difluoromethoxy-1,1,1,2,3,3,3-eptafluoro-propane "

performed at 20 0 °C ± 2.0 °C was 28.6 mg/L.

The solubility in water of the test item expressed as SOLVENT N1 at 20 0 °C ± 2.0 °C was 37.9 mg/L.

The pH of the aqueous samples was 3.66 to 3.83

Key value for chemical safety assessment

Water solubility:
37.9 mg/L
at the temperature of:
20 °C

Additional information