Registration Dossier
Registration Dossier
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EC number: 216-983-6 | CAS number: 1712-64-7
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- chronic toxicity: dermal
- Type of information:
- not specified
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Hygiene of labour
- Author:
- Zaugliikov S. D., Predtechenskiy M. B
- Year:
- 1 967
- Bibliographic source:
- Not specified
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No principles of method were specified.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Isopropyl nitrate
- EC Number:
- 216-983-6
- EC Name:
- Isopropyl nitrate
- Cas Number:
- 1712-64-7
- Molecular formula:
- C3H7NO3
- IUPAC Name:
- propan-2-yl nitrate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- other: not specified
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Dermal irritation:
- effects observed, treatment-related
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- Formation of methemoglobin.
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Neuropathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- not specified
Effect levels
- Dose descriptor:
- NOAEL
- Remarks on result:
- not measured/tested
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Possible poisoning through the skin.
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